76196-79-7

Usage

Uses

Used in Pharmaceutical Synthesis:
2-CYANO-5-ETHOXYCARBONYLPYRIDINE is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the formation of complex molecular structures that can exhibit therapeutic properties.
Used in Agrochemical Synthesis:
In the agrochemical industry, 2-CYANO-5-ETHOXYCARBONYLPYRIDINE is utilized as an intermediate to develop compounds that can be used in crop protection and other agricultural applications, leveraging its reactivity and structural features to create effective products.
Used as a Nucleophilic Catalyst in Organic Chemistry:
2-CYANO-5-ETHOXYCARBONYLPYRIDINE is employed as a nucleophilic catalyst in various chemical reactions, taking advantage of its electron-withdrawing cyano group to facilitate or enhance the reactivity of other molecules in the reaction process.
Used as a Building Block in Organic Synthesis:
As an important building block in organic chemistry, 2-CYANO-5-ETHOXYCARBONYLPYRIDINE is used to create a wide range of compounds, providing a starting material that can be modified and functionalized to achieve desired chemical properties and applications.

Upstream product

• 14906-63-9 1-oxy-nicotinic acid ethyl ester 
• 7677-24-9 trimethylsilyl cyanide 
• 151-50-8 potassium cyanide 
• 64-17-5 ethanol 
• 7732-18-5 water 
• 145432-77-5 3-ethoxycarbonyl-1-methoxy-pyridinium; methyl sulfate 
• 614-18-6 3-pyridinecarboxylic acid ethyl ester 

Downstream Products

• 1446321-37-4 2-(imidazo[1,5-a]pyridin-6-ylmethoxy)-5-methoxybenzaldehyde 
• 1189434-55-6 ethyl 6-(aminomethyl)-3-pyridinecarboxylate hydrochloride 
• 256935-75-8 ethyl imidazo[1,5-a]pyridine-6-carboxylate 

Relevant academic research and scientific papers

SUBSTITUTED HETEROARYL ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION

Provided are substituted heteroaryl aldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.

SUBSTITUTED BENZALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION

Provided are substituted benzaldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.

SUBSTITUTED HETEROARYL ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION

Provided are substituted heteroaryl aldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.

Preparation of cyanopyridines by direct cyanation

After pretreatment with nitric acid and trifluoroacetic anhydride, aqueous potassium cyanide converted pyridines 1a-1 into their corresponding 2-cyano derivatives 4a-1 in an average yield of 52%. Georg Thieme Verlag Stuttgart.

Site-Selectivity in the Cyanation of 3-Substituted Pyridine 1-Oxides with Trimethylsilanecarbonitrile

The cyanation of 3-halo-, 3-methoxy-, and 3-dimethylaminopyridine 1-oxide with trimethylsilanecarbonitrile gave predominantly the corresponding 3-substituted 2-pyridinecarbonitriles.The deoxygenation of nitropyridine 1-oxides to nitropyridines with the same reagent is also described.Keywords - site-selective reaction; trimethylsilanecarbonitrile; pyridine 1-oxide; 2-pyridine-carbonitrile; nitropyridine 1-oxide; deoxygenation; aromatic amine N-oxide; cyanation