5-chloro-2-methoxycarbonyloxy-indole- 1-carboxylic acid methyl ester

Base Information

• Chemical Name: 5-chloro-2-methoxycarbonyloxy-indole- 1-carboxylic acid methyl ester
• CAS No.: 197776-01-5
• Molecular Formula: C₁₂H₁₀ClNO₅
• Molecular Weight: 283.668
• Mol file: 197776-01-5.mol

Synonyms:5-chloro-2-methoxycarbonyloxy-indole- 1-carboxylic acid methyl ester

Chemical Property of 5-chloro-2-methoxycarbonyloxy-indole- 1-carboxylic acid methyl ester

Chemical Property:

• PSA: 66.76000
• LogP: 3.05440

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-chloro-2-methoxycarbonyloxy-indole- 1-carboxylic acid methyl ester

There total 1 articles about 5-chloro-2-methoxycarbonyloxy-indole- 1-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

5-chloro-indolin-2-one (17630-75-0) + methyl chloroformate (79-22-1) → 5-chloro-1-methoxycarbonyl-2-(methoxycarbonyloxy)indole (197776-01-5)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1016/S0040-4020(00)00477-4

Reference yield:

5-chloro-1-methoxycarbonyl-2-(methoxycarbonyloxy)indole (197776-01-5) → 5-chloro-2-phenoxycarbonyloxy-indole-1-carboxylic acid methyl ester (301700-22-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / ammonium carbonate / dimethylformamide / 6 h / 20 °C

2: 81 percent / triethylamine / tetrahydrofuran / 0.5 h / 20 °C

With ammonium carbonate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Hydrolysis / 2: Acylation;

DOI:10.1016/S0040-4020(00)00477-4

Reference yield:

5-chloro-1-methoxycarbonyl-2-(methoxycarbonyloxy)indole (197776-01-5) → 5-Chloro-2-hydroxy-indole-1,3-dicarboxylic acid 1-methyl ester 3-phenyl ester; compound with dimethyl-pyridin-4-yl-amine

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / ammonium carbonate / dimethylformamide / 6 h / 20 °C

2: 81 percent / triethylamine / tetrahydrofuran / 0.5 h / 20 °C

3: 88 percent / dimethylformamide / 0.17 h / 0 - 2 °C

With ammonium carbonate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Hydrolysis / 2: Acylation / 3: Rearrangement;

DOI:10.1016/S0040-4020(00)00477-4

upstream raw materials:

5-chloro-indolin-2-one

methyl chloroformate

Downstream raw materials:

5-chloro-2-phenoxycarbonyloxy-indole-1-carboxylic acid methyl ester