17630-75-0

Basic information

• Product Name: 5-Chlorooxindole
• Synonyms: 4-chloroindole-2(3h)-one;3-dihydroindole-2-one;5-Chlorooxindole ,99%;5-CHLOROOXINDOLE, 97+%;5-Chloro-1H-indol-2(3H)-one;5-Chorooxindole;5-Chloro-2-oxindole,5-Chlorooxindole;1H-indol-5-yl hypochlorite
• CAS NO: 17630-75-0
• Molecular Formula: C₈H₆ClNO
• Molecular Weight: 167.59
• EINECS: 412-200-9
• Product Categories: oxindoles;blocks;IndolesOxindoles;Indole/indoline/oxindole;Indole and Indoline;Indoles and derivatives;Indole;Indoles;Heterocycles
• Mol File: 17630-75-0.mol
• Article Data: 47

Chemical Properties

• Melting Point: 194-197 °C(lit.)
• Boiling Point: 348.3 °C at 760 mmHg
• Flash Point: 164.5 °C
• Appearance: Tan powder
• Density: 1.362 g/cm³
• Vapor Pressure: 0.00881mmHg at 25°C
• Refractive Index: 1.663
• Storage Temp.: Keep Cold
• Solubility: Slightly Soluble (2.0 g/L) (25°C).
• PKA: 13.14±0.20(Predicted)
• CAS DataBase Reference: 5-Chlorooxindole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chlorooxindole(17630-75-0)
• EPA Substance Registry System: 5-Chlorooxindole(17630-75-0)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-43-52/53-62-36/37/38
• Safety Statements: 22-36/37-61-45-36/37/39-24-37/39-26
• WGK Germany: 2
• Hazardous Substances Data: 17630-75-0(Hazardous Substances Data)

Usage

Chemical Properties

Tan powder

Uses

Different sources of media describe the Uses of 17630-75-0 differently. You can refer to the following data:
1. 5-Chlorooxindole is used in the preparation of novel GSK-3β inhibitors as anticancer agents.
2. 5-Chloro-2-oxindole was used for the quantitation of 5-chloro-2-oxindole, concomitantly with all of its potential positional isomers using a single, highly specific, normal-phase chromatographic system. 5-Chloro-2-oxindole (5-Chlorooxindole) is a starting material for tenidap sodium, a pharmaceutical drug candidate.
3. 5-Chloro-2-oxindole was used for the quantitation of 5-chloro-2-oxindole, concomitantly with all of its potential positional isomers using a single, highly specific, normal-phase chromatographic system.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 25, p. 1279, 1988 DOI: 10.1002/jhet.5570250501

General Description

5-Chloro-2-oxindole (5-Chlorooxindole) is a starting material for tenidap sodium, a pharmaceutical drug candidate.

InChI:InChI=1/C8H4ClNO/c9-6-1-2-7-5(3-6)4-8(11)10-7/h1-4H

Upstream product

• 65816-14-0 1-methoxyindolin-2-one 
• 138343-87-0 2-(N-tert-butoxycarbonyl)amino-5-chlorophenylacetic acid 
• 17630-76-1 5-chloroindole 2,3-dione 
• 197776-00-4 phenyl 5-chloro-2-[(phenoxycarbonyl)oxy]-1H-indole-1-carboxylate 
• 539-03-7 N-(4-chlorophenyl)acetamide 
• 623-48-3 ethyl iodoacetae 
• 17422-32-1 5-chloro-1H-indole 
• 113423-48-6 3,3-Dibromo-5-chloroindol-2(3H)-one 
• 3289-75-6 2-chloro-N-(4-chlorophenyl)acetamide 
• 59-48-3 2-oxoindole 
• 71-55-6 1,1,1-trichloroethane 
• 1878-65-5 3-chlorophenylacetic acid 
• 2593-90-0 2-(3-chlorophenyl)acetyl hydroxamic acid 
• 1351706-37-0 N-(2-iodo-4-chlorophenyl)-4-methylbenzenesulfonamide 

Downstream Products

• 197775-85-2 5-chloro-1-ethoxycarbonyl-2-(ethoxycarbonyloxy)indole 
• 197775-88-5 benzyl 2-{[(benzyloxy)carbonyl]oxy}-5-chloro-1H-indole-1-carboxylate 
• 265994-69-2 4-nitrophenyl (5-chloro-2,3-dihydro-2-oxo-1H-indole-1-carboxylate) 
• 197776-01-5 5-chloro-1-methoxycarbonyl-2-(methoxycarbonyloxy)indole 
• 197776-00-4 phenyl 5-chloro-2-[(phenoxycarbonyl)oxy]-1H-indole-1-carboxylate 
• 100487-33-0 1-(N-benzoylcarbamoyl)-5-chlorooxindole 
• 1148119-10-1 (E)-5-chloro-3-(3-methoxybenzylidene)-dihydro-indol-2-one 
• 500572-08-7 C₈H₈ClNO₂ 
• 1194552-11-8 5-chloro-3-((2-(p-tolylamino)thiazol-5-yl)methyl)indolin-2-one 
• 120210-48-2 tenidap 
• 255712-65-3 5-chloro-1-phenoxycarbonyl-2-(thenoyloxy)indole 
• 255712-72-2 (Z)-5-chloro-3-[1-hydroxy-1-(2-thienyl)methylene]-2-oxo-1-phenoxycarbonyl-2,3-dihydroindole 

Relevant articles and documents

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