2-(Bromomethyl)-6-methoxypyridine

Base Information

• Chemical Name: 2-(Bromomethyl)-6-methoxypyridine
• CAS No.: 156094-63-2
• Molecular Formula: C7H8BrNO
• Molecular Weight: 202.051
• Hs Code.: 2933399090
• European Community (EC) Number: 813-670-1
• DSSTox Substance ID: DTXSID00435292
• Nikkaji Number: J582.100B
• Wikidata: Q82250116
• Mol file: 156094-63-2.mol

Synonyms:2-(Bromomethyl)-6-methoxypyridine;156094-63-2;2-bromomethyl-6-methoxypyridine;SCHEMBL18705;2-Methoxy-6-bromomethylpyridine;2-bromomethyl-6-methoxy-pyridine;DTXSID00435292;XHWDFGQAXHSIMH-UHFFFAOYSA-N;AMY30299;MFCD16607559;AKOS016002333;CS-W006716;Pyridine, 2-(bromomethyl)-6-methoxy-;DS-17004;EN300-1896246;J-506267

Chemical Property of 2-(Bromomethyl)-6-methoxypyridine

Chemical Property:

• PSA: 22.12000
• LogP: 1.98510
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 200.97893
• Heavy Atom Count: 10
• Complexity: 99.6

Purity/Quality:

97% ^*data from raw suppliers

2-(Bromomethyl)-6-methoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC(=N1)CBr

Technology Process of 2-(Bromomethyl)-6-methoxypyridine

There total 10 articles about 2-(Bromomethyl)-6-methoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(6-methoxy-pyridin-2-yl)-methanol (63071-12-5) → 2-(bromomethyl)-6-methoxypyridine (156094-63-2)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 20 ℃; for 0.666667h; Inert atmosphere;

Reference yield: 66.0%

2-methoxy-6-methyl-pyridine (63071-03-4) → 2-(bromomethyl)-6-methoxypyridine (156094-63-2)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 8h; Inert atmosphere; Reflux;

DOI:10.1246/bcsj.20150062

Reference yield: 6.0%

2-methoxy-6-methyl-pyridine (63071-03-4) → 2-(bromomethyl)-6-methoxypyridine (156094-63-2) + 6-dibromomethyl-2-methoxypyridine

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); acetic acid; In tetrachloromethane; at 45 - 60 ℃; Irradiation;

DOI:10.1080/00397919408011740

upstream raw materials:

2-methoxy-6-methyl-pyridine

6-hydroxy-2-methylpyridine

(6-methoxy-pyridin-2-yl)-methanol

6-methoxy-pyridine-2-carboxylic acid methyl ester

Downstream raw materials:

ethyl N-(diphenylmethylidene)-3-(6-methoxy-2-pyridinyl)alaninate

1,1,1,3,3,3-hexafluoro-2-(4-(2-((6-methoxy-2-pyridinyl)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

2‐(6‐methoxypyridin‐2‐yl)acetonitrile