2-Methoxy-6-methylpyridine

Base Information

• Chemical Name: 2-Methoxy-6-methylpyridine
• CAS No.: 63071-03-4
• Molecular Formula: C7H9NO
• Molecular Weight: 123.155
• Hs Code.: 29333990
• European Community (EC) Number: 676-191-5
• DSSTox Substance ID: DTXSID70415945
• Nikkaji Number: J582.098G
• Wikidata: Q72490280
• Mol file: 63071-03-4.mol

Synonyms:2-Methoxy-6-methylpyridine;63071-03-4;2-methoxy-6-methyl-pyridine;2-methoxy-6-picoline;6-Methoxy-2-picoline;MFCD04112507;2-Methoxy-6-Methylam;6-methoxy-2-methylpyridine;SCHEMBL128705;2-Methyl-6-(methyloxy)pyridine;DTXSID70415945;WIMNZMOEBDPZTB-UHFFFAOYSA-N;AKOS006222932;AC-5158;AM87109;CS-W003150;PS-6289;SB52307;BP-10295;A8706;FT-0640868;M1695;EN300-131425;A825291;J-509844;2-methoxy-6-methylpyridine;2-METHOXY-6-METHYL-PYRIDINE;InChI=1/C7H9NO/c1-6-4-3-5-7(8-6)9-2/h3-5H,1-2H

Chemical Property of 2-Methoxy-6-methylpyridine

Chemical Property:

• Appearance/Colour: Colorless liquid
• Vapor Pressure: 0.062mmHg at 25°C
• Refractive Index: 1.4995
• Boiling Point: 161.3 °C at 760 mmHg
• PKA: 4.12±0.10(Predicted)
• Flash Point: 56 °C
• PSA: 22.12000
• Density: 1.001 g/cm³
• LogP: 1.39860
• Storage Temp.: Inert atmosphere,Room Temperature
• Water Solubility.: Slightly soluble in water.
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 123.068413911
• Heavy Atom Count: 9
• Complexity: 85

Purity/Quality:

98%, ^*data from raw suppliers

2-Methoxy-6-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 20/21/22-36/38-10
• Safety Statements: 26-36/37/39-36/37-23-9

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC(=CC=C1)OC
• Uses: 2-Methoxy-6-methylpyridine is used as a pharmaceutical intermediate.

Technology Process of 2-Methoxy-6-methylpyridine

There total 15 articles about 2-Methoxy-6-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

6-hydroxy-2-methylpyridine (3279-76-3,91914-07-7) + methyl iodide (74-88-4) → 2-methoxy-6-methyl-pyridine (63071-03-4)

Guidance literature:

With silver carbonate; In dichloromethane;

DOI:10.1016/S0040-4039(97)01422-6

Reference yield: 93.0%

→ 2-methoxy-6-methyl-pyridine (63071-03-4)

Guidance literature:

Reference yield: 80.0%

2-bromo-6-methylpyridine (5315-25-3) + methanol (67-56-1) → 2-methoxy-6-methyl-pyridine (63071-03-4)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 100 ℃;

upstream raw materials:

2-bromo-6-methylpyridine

sodium methylate

6-hydroxy-2-methylpyridine

methyl iodide

Downstream raw materials:

2-methoxy-6-methylpyridine

6-hydroxy-2-methylpyridine

3-bromo-6-methoxy-2-methylpyridine

3-bromo-2-methoxy-6-methylpyridine