2-Chloro-4-iodonicotinonitrile

Base Information

• Chemical Name: 2-Chloro-4-iodonicotinonitrile
• CAS No.: 1171919-75-7
• Molecular Formula: C6H2ClIN2
• Molecular Weight: 264.453
• Hs Code.: 2933399090
• Mol file: 1171919-75-7.mol

Synonyms:2-Chloro-4-iodonicotinonitrile;2-Chloro-3-cyano-4-iodopyridine;2-Chloro-4-iodo-3-pyridinecarbonitrile

Chemical Property of 2-Chloro-4-iodonicotinonitrile

Chemical Property:

• Melting Point: 142-147°C
• Boiling Point: 349.2±42.0 °C(Predicted)
• PKA: -2.34±0.10(Predicted)
• PSA: 36.68000
• Density: 2.13±0.1 g/cm3(Predicted)
• LogP: 2.21128

Purity/Quality:

98%Min ^*data from raw suppliers

2-Chloro-4-iodonicotinonitrile ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-4-iodonicotinonitrile

There total 2 articles about 2-Chloro-4-iodonicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

2-chloro-3-pyridinecarbonitrile (6602-54-6) → 2-chloro-4-iodopyridine-3-carbonitrile (1171919-75-7)

Guidance literature:

2-chloro-3-pyridinecarbonitrile; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 - -30 ℃; for 1h; Inert atmosphere;

With iodine; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

Reference yield:

2-Chloro-4-iodo-3-pyridinecarboxaldehyde (153034-90-3) → 2-chloro-4-iodopyridine-3-carbonitrile (1171919-75-7)

Guidance literature:

With ammonium hydroxide; iodine; In tetrahydrofuran; at 20 ℃;

Reference yield: 99.8%

2-chloro-4-iodopyridine-3-carbonitrile (1171919-75-7) + 3-fluoro-2-methyl-4-phenoxyaniline → 2-chloro-4-((3-fluoro-2-methyl-4-phenoxyphenyl)amino)nicotinonitrile

Guidance literature:

With potassium phosphate; palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether; In 1,4-dioxane; for 4h; Reflux; Inert atmosphere;

upstream raw materials:

2-Chloro-4-iodo-3-pyridinecarboxaldehyde

2-chloro-3-pyridinecarbonitrile

Refernces

• 1、 -. "N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS". Page/Page column 97. . Retrieved 2010/12/29.