4-[(4-Fluorophenoxy)methyl]piperidine hydrochloride

Base Information

Chemical Name:4-[(4-Fluorophenoxy)methyl]piperidine hydrochloride
CAS No.:614731-44-1
Molecular Formula:C12H17ClFNO
Molecular Weight:245.724
Hs Code.:
DSSTox Substance ID:DTXSID70589392
Mol file:614731-44-1.mol

Synonyms:614731-44-1;4-[(4-Fluorophenoxy)methyl]piperidine hydrochloride;4-[(4-Fluorophenoxy)methyl]piperidinehydrochloride;4-((4-Fluorophenoxy)methyl)piperidine hydrochloride;4-[(4-fluorophenoxy)methyl]piperidine;hydrochloride;4-[(4-Fluorophenoxy)methyl]piperidine HCl;4-((4-FLUOROPHENOXY)METHYL)PIPERIDINE HCl;4-(4-fluorophenoxymethyl)piperidine hydrochloride;SCHEMBL1476773;DTXSID70589392;DNWBPFYWQAZTII-UHFFFAOYSA-N;AKOS005111343;CS-0326868;F79462;4-[(4-Fluorophenoxy)methyl]piperidine--hydrogen chloride (1/1)

Suppliers and Price of 4-[(4-Fluorophenoxy)methyl]piperidine hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
4-[(4-Fluorophenoxy)methyl]piperidinehydrochloride
500mg
$ 181.00

Aronis compounds
4-[(4-fluorophenoxy)methyl]piperidinehydrochloride
5mg
$ 15.00

American Custom Chemicals Corporation
4-[(4-FLUOROPHENOXY)METHYL]PIPERIDINE HYDROCHLORIDE 95.00%
500MG
$ 376.95

AK Scientific
4-[(4-Fluorophenoxy)methyl]piperidinehydrochloride
500mg
$ 294.00

Acrotein
4-[(4-Fluorophenoxy)methyl]piperidineHCl 97%
1g
$ 302.50

Acrotein
4-[(4-Fluorophenoxy)methyl]piperidineHCl 97%
0.5g
$ 201.67

Total 3 raw suppliers

Chemical Property of 4-[(4-Fluorophenoxy)methyl]piperidine hydrochloride

Chemical Property:

PSA：21.26000
LogP:3.33490
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:245.0982700
Heavy Atom Count:16
Complexity:175

Purity/Quality:

98%min ^*data from raw suppliers

4-[(4-Fluorophenoxy)methyl]piperidinehydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CNCCC1COC2=CC=C(C=C2)F.Cl

Technology Process of 4-[(4-Fluorophenoxy)methyl]piperidine hydrochloride

There total 2 articles about 4-[(4-Fluorophenoxy)methyl]piperidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: (+/-)-4-[(4-fluorophenyl)hydroxy]methyl-1-piperidinecarboxylic acid, 1,1-dimethyl-ethylester

: 614731-44-1
4-[(4-fluorophenoxy)methyl]piperidine hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; Cooling;

Reference yield:

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: 614731-44-1
4-[(4-fluorophenoxy)methyl]piperidine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane; dichloromethane / 20 °C / Cooling

With hydrogenchloride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; 1: Mitsunobu reaction;

Reference yield: 45.0%

: 614731-44-1
4-[(4-fluorophenoxy)methyl]piperidine hydrochloride

: (E)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylic acid hydrochloride

: 1309205-40-0
6-[(1E)-3-{[4-(4-fluorophenoxy)methyl]piperidin-1-yl}-3-oxoprop-1-en-1-yl]-3,4-dihydro-1,8-naphthyridin-2(1H)-one

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;