3-[(4-ethylphenyl)amino]propanoic acid

Base Information

• Chemical Name: 3-[(4-ethylphenyl)amino]propanoic acid
• CAS No.: 263896-26-0
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.246
• Mol file: 263896-26-0.mol

Synonyms:3-[(4-ethylphenyl)amino]propanoic acid;OTAVA-BB 1142593;UKRORGSYN-BB BBV-215976

Chemical Property of 3-[(4-ethylphenyl)amino]propanoic acid

Chemical Property:

• Boiling Point: 381.3±35.0 °C(Predicted)
• PKA: 3.59±0.12(Predicted)
• PSA: 49.33000
• Density: 1.141±0.06 g/cm3(Predicted)
• LogP: 2.20860

Purity/Quality:

3-[(4-ETHYLPHENYL)AMINO]PROPANOIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-[(4-ethylphenyl)amino]propanoic acid

There total 1 articles about 3-[(4-ethylphenyl)amino]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

β-Propiolactone (57-57-8) + 4-aminoethylbenzene (589-16-2) → 3-(4-ethylphenylamino)propionic acid (263896-26-0)

Guidance literature:

In acetonitrile; for 4h; Heating;

DOI:10.1021/jm025502x

Reference yield: 76.0%

3-(4-ethylphenylamino)propionic acid (263896-26-0) → 6-ethyl-2,3-dihydro-1H-quinolin-4-one (263896-27-1)

Guidance literature:

With phosphorus pentaoxide; PPA; at 100 ℃; for 2h;

DOI:10.1021/jm025502x

Reference yield:

3-(4-ethylphenylamino)propionic acid (263896-26-0) → 5-[2-[(4-ethylphenyl)amino]ethyl]-4-(1-hydrazinylethylidene)-2,4-dihydro-3H-pyrazol-3-one

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine / 30 h / Reflux; Dean-Stark

2: hydrazine hydrate / methanol / 7.5 h / Reflux

With piperidine; hydrazine hydrate; In methanol;

DOI:10.1002/jhet.2857

upstream raw materials:

β-Propiolactone

4-aminoethylbenzene

Downstream raw materials:

6-ethyl-2,3-dihydro-1H-quinolin-4-one

Refernces