(S)-benzyl 1-oxo-1-(2-oxo-2-phenylethylaMino)propan-2-ylcarbaMate

Base Information

• Chemical Name: (S)-benzyl 1-oxo-1-(2-oxo-2-phenylethylaMino)propan-2-ylcarbaMate
• CAS No.: 864825-19-4
• Molecular Formula: C19H20N2O4
• Molecular Weight: 340.379
• Mol file: 864825-19-4.mol

Synonyms:(S)-benzyl 1-oxo-1-(2-oxo-2-phenylethylaMino)propan-2-ylcarbaMate;[(1S)-1-Methyl-2-oxo-2-[(2-oxo-2-phenylethyl)amino]ethyl]carbamic acid phenylmethyl ester;[1-(2-oxo-2-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzyl ester

Chemical Property of (S)-benzyl 1-oxo-1-(2-oxo-2-phenylethylaMino)propan-2-ylcarbaMate

Chemical Property:

• PSA: 84.50000
• LogP: 3.08220

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (S)-Benzyl (1-Oxo-1-((2-oxo-2-phenylethyl)amino)propan-2-yl)carbamate is an impurity of Eluxadoline (E508195), an orally-active drug used to reduce symptoms of irritable bowel syndrome such as diarrhea and abdominal pain.

Technology Process of (S)-benzyl 1-oxo-1-(2-oxo-2-phenylethylaMino)propan-2-ylcarbaMate

There total 1 articles about (S)-benzyl 1-oxo-1-(2-oxo-2-phenylethylaMino)propan-2-ylcarbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

N-Cbz-Ala (1142-20-7) + 2-aminoacetophenone hydrochloride (5468-37-1) → benzyl (S)-(1-oxo-1-((2-oxo-2-phenylethyl)amino)propan-2-yl)carbamate (864825-19-4)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃;

Reference yield: 95.0%

benzyl (S)-(1-oxo-1-((2-oxo-2-phenylethyl)amino)propan-2-yl)carbamate (864825-19-4) → benzyl [(1S)-1-(4-phenyl-1H-imidazol-2-yl)ethyl]carbamate (864825-21-8)

Guidance literature:

With ammonium acetate; acetic acid; In xylene; for 7h; Heating / reflux;

Reference yield:

benzyl (S)-(1-oxo-1-((2-oxo-2-phenylethyl)amino)propan-2-yl)carbamate (864825-19-4) → benzyl [(1S)-1-(5-phenyl-1H-imidazol-2-yl)ethyl]carbamate

Guidance literature:

With ammonium acetate; acetic acid; In toluene; at 40 - 110 ℃; Solvent;

upstream raw materials:

N-Cbz-Ala

2-aminoacetophenone hydrochloride

Downstream raw materials:

benzyl [(1S)-1-(4-phenyl-1H-imidazol-2-yl)ethyl]carbamate

(2-(4-hydroxy-2,6-dimethyl-phenyl)-1-{isopropyl-[1-(4-phenyl-1H-imidazol-2-yl)-ethyl]-carbamoyl}-ethyl)-carbamic acid tert-butyl ester