8-Benzyloxyadenosine

Base Information

• Chemical Name: 8-Benzyloxyadenosine
• CAS No.: 131265-29-7
• Molecular Formula: C₁₇H₁₉N₅O₅
• Molecular Weight: 373.368
• Mol file: 131265-29-7.mol

Synonyms:8-Benzyloxyadenosine

Chemical Property of 8-Benzyloxyadenosine

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-Benzyloxyadenosine

There total 4 articles about 8-Benzyloxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

C35H61N5O5Si3 → 8-Benzyloxyadenosine (131265-29-7)

Guidance literature:

With ammonium fluoride; In methanol; for 48h; Reflux;

DOI:10.1021/ml500343r

Reference yield:

8-bromoadenosine (2946-39-6) → 8-Benzyloxyadenosine (131265-29-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 20 h / 20 °C / Cooling with ice

2: potassium tert-butylate / 48 h / 40 °C

3: ammonium fluoride / methanol / 48 h / Reflux

With 1H-imidazole; ammonium fluoride; potassium tert-butylate; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/ml500343r

Reference yield:

8-bromo-[2',3',5'-tris-(dimethyl-tert-butylsilyl)]adenosine (175164-91-7) → 8-Benzyloxyadenosine (131265-29-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / 48 h / 40 °C

2: ammonium fluoride / methanol / 48 h / Reflux

With ammonium fluoride; potassium tert-butylate; In methanol;

DOI:10.1021/ml500343r

upstream raw materials:

8-bromoadenosine

benzyl alcohol

8-bromo-[2',3',5'-tris-(dimethyl-tert-butylsilyl)]adenosine

Downstream raw materials:

(2R,3R,4S,5R)-2-(6-Amino-8-benzyloxy-purin-9-yl)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3,4-diol

8-bromoadenosine

Imidazole-1-carbothioic acid O-[(2R,3S,5R)-5-(6-amino-8-benzyloxy-purin-9-yl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl] ester

(3aR,4R,6R,6aR)-4-(6-Amino-8-benzyloxy-purin-9-yl)-6-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furo[3,4-d][1,3]dioxole-2-thione