PF-3274167

Base Information

Chemical Name:PF-3274167
CAS No.:900510-03-4
Molecular Formula:C₁₉H₁₉ClFN₅O₃
Molecular Weight:419.843
Hs Code.:

Synonyms:PF-3274167;PF-03274167;5-[3-[3-(2-Chloro-4-fluorophenoxy)-1-azetidinyl]-5-(methoxymethyl)-4H-1,2,4-triazol-4-yl]-2-methoxypyridine

Suppliers and Price of PF-3274167

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
PF 3274167
100mg
$ 1890.00

TRC
PF-3274167
50mg
$ 915.00

DC Chemicals
PF-3274167（cligosiban） >98%
1 g
$ 1900.00

DC Chemicals
PF-3274167（cligosiban） >98%
250 mg
$ 900.00

Crysdot
PF-3274167 98+%
5mg
$ 139.00

Crysdot
PF-3274167 98+%
10mg
$ 200.00

Crysdot
PF-3274167 98+%
50mg
$ 672.00

Crysdot
PF-3274167 98+%
100mg
$ 1120.00

Chemenu
5-(3-(3-(2-chloro-4-fluorophenoxy)azetidin-1-yl)-5-(methoxymethyl)-4H-1,2,4-triazol-4-yl)-2-methoxypyridine 98%
100mg
$ 1047.00

Cayman Chemical
PF-3274167
10mg
$ 177.00

Total 15 raw suppliers

Chemical Property of PF-3274167

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

PF 3274167 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description PF-3274167 is an oxytocin receptor antagonist (Ki = 9.5 nM). It is selective for the oxytocin receptor over the vasopressin receptors V1A and V2 (Kis = 1,120 and 10,000 nM, respectively).
Uses PF-3274167 functions as s triazole oxytocin antagonists. It also functions as a PET radiotracer of oxytocin receptors.

Technology Process of PF-3274167

There total 3 articles about PF-3274167 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 900512-31-4
C₁₇H₁₇ClFN₃O₂S

: 20605-41-8
methoxyacetic acid hydrazide

: 900510-03-4
(5-(3-(3-(2-chloro-4-fluorophenoxy)azetidin-1-yl)-5-(methoxymethyl)-4H-1,2,4-triazol-4-yl)-2-methoxypyridine)

Guidance literature:: With trifluoroacetic acid; In tetrahydrofuran; for 1.5h; Reflux;
DOI:10.1055/s-2008-1078208

Reference yield: 52.0%

: 20605-41-8
methoxyacetic acid hydrazide

: 900510-03-4
(5-(3-(3-(2-chloro-4-fluorophenoxy)azetidin-1-yl)-5-(methoxymethyl)-4H-1,2,4-triazol-4-yl)-2-methoxypyridine)

Guidance literature:: 3-(2-chloro-4-fluorophenoxy)-N-(6-methoxypyridin-3-yl)azetidine-1-carbothioamide; With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃; for 0.333333h;

With methyl p-toluene sulfonate; In tetrahydrofuran; at 20 ℃; for 0.666667h;

methoxyacetic acid hydrazide; With trifluoroacetic acid; In tetrahydrofuran; for 1.5h; Product distribution / selectivity; Heating / reflux;