2-((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)-5-chlorobenzoic acid

Base Information

Chemical Name:2-((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)-5-chlorobenzoic acid
CAS No.:1460036-97-8
Molecular Formula:C₁₇H₂₃ClN₂O₄
Molecular Weight:354.834
Hs Code.:

Synonyms:2-((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)-5-chlorobenzoic acid

Suppliers and Price of 2-((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)-5-chlorobenzoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)-5-chlorobenzoic acid

Chemical Property:

Purity/Quality:: 98%min ^*data from raw suppliers

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Technology Process of 2-((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)-5-chlorobenzoic acid

There total 3 articles about 2-((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)-5-chlorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1460036-94-5
tert-butyl 4-[[4-chloro-2-(methoxycarbonyl)phenyl]methyl]piperazine-1-carboxylate

: 1460036-97-8
2-((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)-5-chlorobenzoic acid

Guidance literature:: With water; lithium hydroxide; In methanol; at 20 ℃; for 3h;

Reference yield:

: 84459-33-6
2-bromo-4-chlorobenzaldehyde

: 1460036-97-8
2-((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)-5-chlorobenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 80 °C / 3800.26 Torr

2.1: 1,2-dichloro-ethane / 0.5 h / 20 °C

2.2: 20 °C

3.1: lithium hydroxide; water / methanol / 3 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; triethylamine; lithium hydroxide; In methanol; 1,2-dichloro-ethane;

Reference yield:

: 1203589-45-0
methyl 5-chloro-2-formylbenzoate

: 1460036-97-8
2-((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)-5-chlorobenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,2-dichloro-ethane / 0.5 h / 20 °C

1.2: 20 °C

2.1: lithium hydroxide; water / methanol / 3 h / 20 °C

With water; lithium hydroxide; In methanol; 1,2-dichloro-ethane;