4-Bromo-3-thiophenecarboxylic acid ethyl ester

Base Information

• Chemical Name: 4-Bromo-3-thiophenecarboxylic acid ethyl ester
• CAS No.: 224449-33-6
• Molecular Formula: C7H7BrO2S
• Molecular Weight: 235.101
• Hs Code.: 2930909899
• Mol file: 224449-33-6.mol

Synonyms:4-Bromo-3-thiophenecarboxylic acid ethyl ester;ethyl 4-bromothiophene-3-carboxylate

Chemical Property of 4-Bromo-3-thiophenecarboxylic acid ethyl ester

Chemical Property:

• Boiling Point: 260.9±20.0 °C(Predicted)
• PSA: 54.54000
• Density: 1.572±0.06 g/cm3(Predicted)
• LogP: 2.68730
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

Ethyl4-bromothiophene-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Bromo-3-thiophenecarboxylic acid ethyl ester

There total 4 articles about 4-Bromo-3-thiophenecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3,4-dibromothiophene (3141-26-2) + chloroformic acid ethyl ester (541-41-3) → 4.-brorno-thiophene-3-carboxylic acid ethyl ester (224449-33-6)

Guidance literature:

3,4-dibromothiophene; With isopropylmagnesium chloride; In tetrahydrofuran; at 0 - 5 ℃; for 5h;

chloroformic acid ethyl ester; In tetrahydrofuran; at 10 - 20 ℃; for 16h;

With water; In tetrahydrofuran; at 20 ℃; for 0.166667h;

Reference yield:

3,4-dibromothiophene (3141-26-2) + isopropylmagnesium chloride (1068-55-9) → 4.-brorno-thiophene-3-carboxylic acid ethyl ester (224449-33-6)

Guidance literature:

In tetrahydrofuran; water;

Reference yield:

3,4-dibromothiophene (3141-26-2) + chloroformic acid ethyl ester (541-41-3) → diethyl thiophene-3,4-dicarboxylate (53229-47-3) + ethyl ester of 3,4-dibromo-2-thiophenecarboxylic acid + 4.-brorno-thiophene-3-carboxylic acid ethyl ester (224449-33-6) + diethyl 4-bromothiophene-2,3-dicarboxylate

Guidance literature:

With n-butyllithium; Yield given; Multistep reaction. Further byproducts given. Yields of byproduct given; 1.) Et₂O, hexane, -116 deg C, 1.5 min, 2.) 20 deg C, 5 min;

DOI:10.1016/S0968-0896(98)00210-7

upstream raw materials:

3,4-dibromothiophene

chloroformic acid ethyl ester

isopropylmagnesium chloride

Downstream raw materials:

4-bromo-3-thiophenecarboxylic acid

6-phenyl-5H-thieno[3,4-c]pyridin-4-one

4-ethoxy-thiophene-3-carboxylic acid

4-(2-oxo-2-phenylethyl)thiophene-3-carboxylic acid

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