2-FLUORO-6-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER

Base Information

• Chemical Name: 2-FLUORO-6-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER
• CAS No.: 1310384-07-6
• Molecular Formula: C12H17BFNO2
• Molecular Weight: 237.08
• Hs Code.: 2934999090
• Mol file: 1310384-07-6.mol

Synonyms:2-FLUORO-6-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER

Chemical Property of 2-FLUORO-6-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER

Chemical Property:

• PSA: 31.35000
• LogP: 1.82830
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-Fluoro-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Fluoro-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine is a useful synthetic intermediate.

Technology Process of 2-FLUORO-6-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER

There total 3 articles about 2-FLUORO-6-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.3%

2-fluoro-6-methylpyridine (407-22-7) + bis(pinacol)diborane (73183-34-3) → 2-fluoro-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1310384-07-6)

Guidance literature:

With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In tert-butyl methyl ether; at 80 ℃; for 14h; Inert atmosphere;

Reference yield:

2-fluoro-6-methylpyridine (407-22-7) + bis(pinacol)diborane (73183-34-3) → 2-fluoro-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1310384-07-6) + 2-fluoro-6-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1218790-38-5)

Guidance literature:

With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; at 80 ℃; for 18h; Overall yield = 75 %; Overall yield = 117 mg; Inert atmosphere; Glovebox;

Reference yield:

→ 2-fluoro-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1310384-07-6)

Guidance literature:

With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In hexane; at 60 ℃; for 0.166667h;

In hexane; at 60 ℃; for 14h;

upstream raw materials:

2-fluoro-6-methylpyridine

bis(pinacol)diborane

Refernces

• 1、 -. "PYRIDYL SUBSTITUTED INDOLE COMPOUNDS". Page/Page column 92-93. . Retrieved 2018/03/28.