4-Piperidino-2-butynoic acid

Base Information

• Chemical Name: 4-Piperidino-2-butynoic acid
• CAS No.: 38346-97-3
• Molecular Formula: C9H13NO2
• Molecular Weight: 0
• Mol file: 38346-97-3.mol

Synonyms:1-Piperidinetetrolic acid;4-Piperidino-2-butynoic acid;4-Piperidinotetrolic acid

Chemical Property of 4-Piperidino-2-butynoic acid

Chemical Property:

• PSA: 40.54000
• LogP: 0.49820

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Piperidino-2-butynoic acid

There total 3 articles about 4-Piperidino-2-butynoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(prop-2-yn-1-yl)piperidine (5799-75-7) + carbon dioxide (124-38-9,18923-20-1) → 4-Piperidinotetrolic acid (38346-97-3)

Guidance literature:

1-(prop-2-yn-1-yl)piperidine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

carbon dioxide; In tetrahydrofuran; hexane; at -78 ℃; Further stages.;

DOI:10.1021/jm0005555

Reference yield:

piperidine (110-89-4) → 4-Piperidinotetrolic acid (38346-97-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 63 percent / Cs₂CO₃ / acetone / 20 °C

2.1: n-BuLi / hexane; tetrahydrofuran / 1 h / -78 °C

2.2: hexane; tetrahydrofuran / -78 °C

With n-butyllithium; caesium carbonate; In tetrahydrofuran; hexane; acetone;

DOI:10.1021/jm0005555

Reference yield:

→ 4-Piperidinotetrolic acid (38346-97-3)

Guidance literature:

aus Cl-CH2-C-=C-COOH, Piperidin;

upstream raw materials:

1-(prop-2-yn-1-yl)piperidine

carbon dioxide

piperidine

Refernces