3-(ChloroMethyl)-N-(5-chloro-2-pyridinyl)-2-pyrazinecarboxaMide

Base Information

• Chemical Name: 3-(ChloroMethyl)-N-(5-chloro-2-pyridinyl)-2-pyrazinecarboxaMide
• CAS No.: 1122549-47-6
• Molecular Formula: C₁₁H₈Cl₂N₄O
• Molecular Weight: 283.117
• Hs Code.: 2934999090
• Mol file: 1122549-47-6.mol

Synonyms:3-(ChloroMethyl)-N-(5-chloro-2-pyridinyl)-2-pyrazinecarboxaMide;3-(Chloromethyl)-N-(5-chloropyridin-2-yl)pyrazine-2-carboxamide

Chemical Property of 3-(ChloroMethyl)-N-(5-chloro-2-pyridinyl)-2-pyrazinecarboxaMide

Chemical Property:

• Boiling Point: 380.6±42.0 °C(Predicted)
• PKA: 9.68±0.70(Predicted)
• PSA: 71.26000
• Density: 1.508±0.06 g/cm3(Predicted)
• LogP: 2.90010
• Solubility.: Dimethyl Sulfoxide

Purity/Quality:

97% ^*data from raw suppliers

3-(Chloromethyl)-N-(5-chloro-2-pyridinyl)-2-pyrazinecarboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-(ChloroMethyl)-N-(5-chloro-2-pyridinyl)-2-pyrazinecarboxaMide is used in the preparation of Eszopiclone (E889150) impurity.

Technology Process of 3-(ChloroMethyl)-N-(5-chloro-2-pyridinyl)-2-pyrazinecarboxaMide

There total 1 articles about 3-(ChloroMethyl)-N-(5-chloro-2-pyridinyl)-2-pyrazinecarboxaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.4%

3-hydroxymethyl-pyrazine-2-carboxylic acid N-(5-chloro-pyridin-2-yl)-amide (1122549-43-2) → 3-chloromethylpyrazine-2-carboxylic acid N-(5-chloro-pyridin-2-yl)-amide (1122549-47-6)

Guidance literature:

With thionyl chloride; In dichloromethane; at 20 ℃; for 2h;

DOI:10.3390/molecules13081817

Reference yield:

3-chloromethylpyrazine-2-carboxylic acid N-(5-chloro-pyridin-2-yl)-amide (1122549-47-6) → 6-(5-chloropyridin-2-yl)-6,7-dihydropyrrolo[3,4-b]pyrazin-5-one (148891-53-6)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.3390/molecules13081817

upstream raw materials:

3-hydroxymethyl-pyrazine-2-carboxylic acid N-(5-chloro-pyridin-2-yl)-amide

Downstream raw materials:

6-(5-chloropyridin-2-yl)-6,7-dihydropyrrolo[3,4-b]pyrazin-5-one