1122549-43-2

Basic information

• Product Name: N-(5-Chloro-2-pyridinyl)-3-(hydroxyMethyl)-2-pyrazinecarboxaMide
• Synonyms: N-(5-Chloro-2-pyridinyl)-3-(hydroxyMethyl)-2-pyrazinecarboxaMide;N-(5-chloropyridin-2-yl)-3-(hydroxymethyl)pyrazine-2-carboxamide;Zopiclone Impurity 2;N-(2-chloropyridin-4-yl)-3-(hydroxymethyl)pyrazine-2-carboxamide
• CAS NO: 1122549-43-2
• Molecular Formula: C11H9ClN4O2
• Molecular Weight: 264.66776
• Product Categories: Amines;Aromatics;Heterocycles;Amines, Aromatics, Heterocycles
• Mol File: 1122549-43-2.mol
• Article Data: 1

Chemical Properties

• Melting Point: 176.0-177.3 °C
• Boiling Point: 397.7±42.0 °C(Predicted)
• Appearance: /
• Density: 1.523±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 9.78±0.70(Predicted)
• CAS DataBase Reference: N-(5-Chloro-2-pyridinyl)-3-(hydroxyMethyl)-2-pyrazinecarboxaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5-Chloro-2-pyridinyl)-3-(hydroxyMethyl)-2-pyrazinecarboxaMide(1122549-43-2)
• EPA Substance Registry System: N-(5-Chloro-2-pyridinyl)-3-(hydroxyMethyl)-2-pyrazinecarboxaMide(1122549-43-2)

Safety Data

• Hazardous Substances Data: 1122549-43-2(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Solid

Uses

N-(5-Chloro-2-pyridinyl)-3-(hydroxyMethyl)-2-pyrazinecarboxaMide is used in the preparation of Eszopiclone (E889150) impurity.

Upstream product

• 43200-81-3 6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one 

Downstream Products

• 1122549-47-6 3-chloromethylpyrazine-2-carboxylic acid N-(5-chloro-pyridin-2-yl)-amide 

Relevant articles and documents

Synthesis of RP 48497, an impurity of eszopiclone

RP 48497 is a photodegradation product of eszopiclone, a non-benzodiazepine sedative-hypnotic used in the treatment of insomnia. We report herein the first synthesis of RP 48497 via reduction, chlorination, and recyclization of 6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydropyrrolo[3,4-b]pyrazin-5-one (3), a key intermediate in the synthesis of eszopiclone. The structure of RP 48497 was confirmed by its 1H-NMR and MS data. The mechanism of the reduction step in the synthesis of RP 48497 was also studied and the key parameters were determined. These findings should be important for quality control purposes in the manufacture of eszopiclone.