4-forMyl-2-Methylbenzoic acid

Base Information

• Chemical Name: 4-forMyl-2-Methylbenzoic acid
• CAS No.: 503470-23-3
• Molecular Formula: C9H8O3
• Molecular Weight: 164.161
• Mol file: 503470-23-3.mol

Synonyms:4-forMyl-2-Methylbenzoic acid

Chemical Property of 4-forMyl-2-Methylbenzoic acid

Chemical Property:

• PSA: 54.37000
• LogP: 1.50570

Purity/Quality:

97% ^*data from raw suppliers

4-formyl-2-methylbenzoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-forMyl-2-Methylbenzoic acid

There total 6 articles about 4-forMyl-2-Methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-(hydroxymethyl)-2-methylbenzoic acid (861555-67-1) → 4-formyl-2-methylbenzoic acid (503470-23-3)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 25 - 35 ℃; for 2h; Reagent/catalyst; Solvent;

Reference yield: 47.0%

4-bromo-2-methylbenzoic acid (68837-59-2) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-formyl-2-methylbenzoic acid (503470-23-3)

Guidance literature:

4-bromo-2-methylbenzoic acid; N,N-dimethyl-formamide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 25 ℃; for 2h;

With hydrogenchloride; water; In tetrahydrofuran; hexane;

Reference yield: 40.0%

4-bromo-2-methylbenzoic acid (68837-59-2) → 4-formyl-2-methylbenzoic acid (503470-23-3)

Guidance literature:

With hydrogenchloride; n-butyllithium; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

4-bromo-2-methylbenzoic acid

N,N-dimethyl-formamide

4-(hydroxymethyl)-2-methylbenzoic acid

4-bromo-2-methyl-benzoic acid methyl ester

Downstream raw materials:

4-(hydroxymethyl)-2-methylbenzoic acid

4-carboethoxy-3-methylbenzaldehyde

ethyl 2-methyl-4-vinylbenzoate

(E)-1-(3-methyl-4-ethoxycarbonyl)phenyl-3-(3,5-dichloro)phenyl-4,4,4-trifluorobut-1-ene