(4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)Methanol

Base Information

• Chemical Name: (4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)Methanol
• CAS No.: 1400755-04-5
• Molecular Formula: C14H21BO3
• Molecular Weight: 248.13
• Mol file: 1400755-04-5.mol

Synonyms:(4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)Methanol;4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenemethanol

Chemical Property of (4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)Methanol

Chemical Property:

• PSA: 38.69000
• LogP: 1.78650
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

(4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)Methanol

There total 2 articles about (4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl)Methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(3-bromo-4-methyl-phenyl)-methanol (68120-35-4) + bis(pinacol)diborane (73183-34-3) → [4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-methanol (1400755-04-5)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 100 ℃; for 15h; Inert atmosphere;

Reference yield:

3-bromo-4-methylbenzoic acid (7697-26-9) → [4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-methanol (1400755-04-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylsulfide borane complex / tetrahydrofuran / 18 h / 0 - 20 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 18 h / 100 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dimethylsulfide borane complex; potassium acetate; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

4-bromo-2-methoxypyridine (100367-39-3) + [4-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-methanol (1400755-04-5) → (3-(2-methoxypyridin-4-yl)-4-methylphenyl)methanol (1544739-91-4)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,4-dioxane; water; at 100 ℃; for 0.166667h; Inert atmosphere; Sealed tube; Microwave irradiation;

upstream raw materials:

3-bromo-4-methylbenzoic acid

(3-bromo-4-methyl-phenyl)-methanol

bis(pinacol)diborane

Downstream raw materials:

4-(5-(bromomethyl)-2-methylphenyl)-2-methoxypyridine

(5aR,6S,6aS)-ethyl 3-((3-(2-methoxypyridin-4-yl)-4-methylbenzyl)oxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate

(5aR,6S,6aS)-3-((3-(2-methoxypyridin-4-yl)-4-methylbenzyl)oxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid

(3-(2-methoxypyridin-4-yl)-4-methylphenyl)methanol

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