2-tert-Amyl-6-(diphenylphosphino)pyridine, ALPYPHOS

Base Information

• Chemical Name: 2-tert-Amyl-6-(diphenylphosphino)pyridine, ALPYPHOS
• CAS No.: 947315-18-6
• Molecular Formula: C22H24NP
• Molecular Weight: 333.413
• Hs Code.: 2933399090
• Mol file: 947315-18-6.mol

Synonyms:2-(1,1-Dimethylpropyl)-6-(diphenylphosphino)pyridine;2-tert-Amyl-6-(diphenylphosphino)pyridine, ALPYPHOS;ALPYPHOS

Chemical Property of 2-tert-Amyl-6-(diphenylphosphino)pyridine, ALPYPHOS

Chemical Property:

• Melting Point: 78-82 °C
• Boiling Point: 428.8±33.0 °C(Predicted)
• PKA: 2.93±0.24(Predicted)
• PSA: 26.48000
• LogP: 4.52740
• Storage Temp.: 2-8°C

Purity/Quality:

99%min ^*data from raw suppliers

2-(1,1-Dimethylpropyl)-6-(diphenylphosphino)pyridine ≥98.0% (HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-tert-Amyl-6-(diphenylphosphino)pyridine, ALPYPHOS

There total 4 articles about 2-tert-Amyl-6-(diphenylphosphino)pyridine, ALPYPHOS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-chloro-6-tert-amylpyridine (1092838-01-1) + diphenylphosphane (829-85-6) → 6-tert-amyl-2-diphenylphosphinopyridine (947315-18-6)

Guidance literature:

diphenylphosphane; With n-butyllithium; In tetrahydrofuran; hexane; at 20 ℃; for 0.5h; Inert atmosphere;

2-chloro-6-tert-amylpyridine; In tetrahydrofuran; hexane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/chem.200900563

Reference yield: 69.0%

2-chloro-6-tert-amylpyridine (1092838-01-1) + sodium diphenylphosphide (4376-01-6) → 6-tert-amyl-2-diphenylphosphinopyridine (947315-18-6)

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1002/anie.200803312

Reference yield:

[RuCl2(η3:η3-(2,7-dimethylocta-2,6-diene-1,8-diyl)){k1-(P)-PPh2(py-6-tert-amyl)}] (1407534-45-5) → 6-tert-amyl-2-diphenylphosphinopyridine (947315-18-6)

Guidance literature:

With dimethylsulfide; In dichloromethane; at 20 ℃; for 96h; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.jorganchem.2012.12.027

upstream raw materials:

2-chloro-6-tert-amylpyridine

sodium diphenylphosphide

diphenylphosphane

[RuCl₂(η³:η³-(2,7-dimethylocta-2,6-diene-1,8-diyl)){k¹-(P)-PPh₂(py-6-tert-amyl)}]

Downstream raw materials:

RuCl2(η⁶-benzene)(κ¹-(P)-PPh2(py-6-tert-amyl))

[RuCl₂(η³:η³-(2,7-dimethylocta-2,6-diene-1,8-diyl)){k¹-(P)-PPh₂(py-6-tert-amyl)}]

[RuCl₂(η³:η³-p-cymene){κ¹-(P)-PPh₂(py-6-tert-amyl)}]

[AuCl{κ¹-(P)-PPh₂(py-6-tert-amyl)}]

Refernces

• 1、 Hintermann, Lukas,Dang, Tuan Thanh,Labonne, Aurelie.,Kribber, Thomas,Xiao, Li,Naumov, Pance. "The AZARYPHOS family of ligands for ambifunctional catalysis: Syntheses and use in ruthenium-catalyzed anti-markovnikov hydration of terminal alkynes". supporting information; experimental part. p. 7167 - 7179. Retrieved 2010/02/28.