tert-butyl 4-(5-nitro-1H-indol-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(5-nitro-1H-indol-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate
• CAS No.: 151273-41-5
• Molecular Formula: C18H21N3O4
• Molecular Weight: 343.37704
• Mol file: 151273-41-5.mol

Synonyms:tert-butyl 4-(5-nitro-1H-indol-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate;4-(5-Nitro-1H-indol-3-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Chemical Property of tert-butyl 4-(5-nitro-1H-indol-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate

Chemical Property:

• Melting Point: 210 - 212 °C
• PSA: 91.15000
• LogP: 4.56140

Purity/Quality:

98% ^*data from raw suppliers

4-(5-Nitro-1H-indol-3-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester ^*data from reagent suppliers

Safty Information:

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Technology Process of tert-butyl 4-(5-nitro-1H-indol-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate

There total 4 articles about tert-butyl 4-(5-nitro-1H-indol-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + 5-nitroindole (6146-52-7) → tert-butyl 4-(5-nitro-1H-indol-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate (151273-41-5)

Guidance literature:

With pyrrolidine; In ethanol; at 20 ℃; for 72h; Heating / reflux;

Reference yield: 79.0%

sodium methylate (124-41-4) + N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + 5-nitroindole (6146-52-7) → tert-butyl 4-(5-nitro-1H-indol-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate (151273-41-5)

Guidance literature:

sodium methylate; N-tert-butyloxycarbonylpiperidin-4-one; 5-nitroindole; at 0 - 85 ℃; for 32h;

With sodium hydroxide; In water; pH=9;

Reference yield: 72.0%

→ tert-butyl 4-(5-nitro-1H-indol-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate (151273-41-5)

Guidance literature:

upstream raw materials:

N-tert-butyloxycarbonylpiperidin-4-one

5-nitroindole

sodium methylate

tert-butyl 3-bromo-5-nitro-1H-indole-1-carboxylate

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