6-BROMO-1-METHYLQUINOLIN-2(1H)-ONE

Base Information

• Chemical Name: 6-BROMO-1-METHYLQUINOLIN-2(1H)-ONE
• CAS No.: 16717-25-2
• Molecular Formula: C10H8BrNO
• Molecular Weight: 238.084
• Hs Code.: 2933790090
• Mol file: 16717-25-2.mol

Synonyms:6-BROMO-1-METHYLQUINOLIN-2(1H)-ONE;6-BROMO-1-METHYL-1H-QUINOLIN-2-ONE;6-Bromo-1-methyl-2(1H)-quinolinone;6-Bromo-1-methylcarbostyril

Chemical Property of 6-BROMO-1-METHYLQUINOLIN-2(1H)-ONE

Chemical Property:

• Melting Point: 144-146℃
• PSA: 22.00000
• LogP: 2.30100
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

6-Bromo-1-methyl-1H-quinolin-2-one 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-BROMO-1-METHYLQUINOLIN-2(1H)-ONE

There total 6 articles about 6-BROMO-1-METHYLQUINOLIN-2(1H)-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-methyl-2-quinolin-2(1H)-one (606-43-9) → 6-bromo-1-methylquinoline-2(1H)-one (16717-25-2)

Guidance literature:

With Eosin Y; Selectfluor; In acetonitrile; at 25 ℃; for 12h; regioselective reaction;

DOI:10.1021/acs.orglett.7b01427

Reference yield: 85.0%

C10H9BrN(1+)*Br(1-) → 6-bromo-1-methylquinoline-2(1H)-one (16717-25-2)

Guidance literature:

With caesium carbonate; In tetrahydrofuran; at 20 ℃; for 12h; Schlenk technique; Irradiation;

DOI:10.1002/chem.202100398

Reference yield:

6-bromo-1,2,3,4-tetrahydroquinoline (22190-35-8) → 6-bromo-1-methylquinoline-2(1H)-one (16717-25-2)

Guidance literature:

Multi-step reaction with 3 steps

1: oxygen / N,N-dimethyl acetamide / 20 °C / Schlenk technique; Irradiation

2: acetonitrile / 100 °C / Inert atmosphere; Schlenk technique

3: caesium carbonate / tetrahydrofuran / 12 h / 20 °C / Schlenk technique; Irradiation

With oxygen; caesium carbonate; In tetrahydrofuran; N,N-dimethyl acetamide; acetonitrile;

DOI:10.1002/chem.202100398

upstream raw materials:

1-methyl-2-quinolin-2(1H)-one

6-bromo-1,2,3,4-tetrahydroquinoline

6-bromoquinoline

Downstream raw materials:

2,6-di-bromoquinoline

6-bromo-1-methyl-3-phenylquinolin-2(1H)-one