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22190-35-8

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22190-35-8 Usage

General Description

6-Bromo-1,2,3,4-tetrahydroquinoline is a chemical compound with the molecular formula C9H10BrN. It is a brominated derivative of tetrahydroquinoline, which is a common structural motif in many biologically active compounds. This chemical has potential applications in the pharmaceutical industry, particularly in the development of new drugs for various medical conditions. It may also be used as an intermediate in the synthesis of other complex organic molecules. Additionally, 6-bromo-1,2,3,4-tetrahydroquinoline could be employed in academic research as a reagent or building block for the preparation of novel compounds with potentially useful biological activities. However, its specific uses and properties would depend on the intended application and the specific characteristics of the compound.

Check Digit Verification of cas no

The CAS Registry Mumber 22190-35-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,1,9 and 0 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 22190-35:
(7*2)+(6*2)+(5*1)+(4*9)+(3*0)+(2*3)+(1*5)=78
78 % 10 = 8
So 22190-35-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H10BrN/c10-8-3-4-9-7(6-8)2-1-5-11-9/h3-4,6,11H,1-2,5H2

22190-35-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-BROMO-1,2,3,4-TETRAHYDROQUINOLINE

1.2 Other means of identification

Product number -
Other names 6-bromo-1,2,3,4-tetrahydro-quinoline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:22190-35-8 SDS

22190-35-8Relevant articles and documents

Fast and Efficient Nickel(II)-catalysed Transfer Hydrogenation of Quinolines with Ammonia Borane

Vermaak, Vincent,Vosloo, Hermanus C. M.,Swarts, Andrew J.

supporting information, p. 5788 - 5793 (2020/12/01)

Herein we report the first Ni(II)-catalysed transfer hydrogenation of quinolines using ammonia borane (AB) as hydrogen (H2) source. An in situ generated Ni(II)-bis(pyrazolyl)pyridine pre-catalyst could hydrogenate quinoline and its derivatives in excellent yields of up to 90% at 25 °C in 30 minutes. Spectroscopic studies revealed that a Ni(II)-hydride is responsible for the transfer hydrogenation of quinoline to 1,2,3,4-tetrahydroquinoline via a 1,4-dihydroquinoline intermediate. (Figure presented.).

Design, structure-activity relationship, and pharmacokinetic profile of pyrazole-based indoline factor Xa inhibitors

Varnes, Jeffrey G.,Wacker, Dean A.,Jacobson, Irina C.,Quan, Mimi L.,Ellis, Christopher D.,Rossi, Karen A.,He, Ming Y.,Luettgen, Joseph M.,Knabb, Robert M.,Bai, Steven,He, Kan,Lam, Patrick Y.S.,Wexler, Ruth R.

, p. 6481 - 6488 (2008/03/18)

A new series of pyrazole-based factor Xa inhibitors have been identified as part of our ongoing efforts to optimize previously reported clinical candidate razaxaban. Concern over the possible formation of primary aniline metabolites via amide hydrolysis led to the replacement of the primary amide linker between the pyrazole and phenyl moieties with secondary amides. This was accomplished by replacing the aniline with a variety of heterobicycles, of which indolines were the most potent. The indoline series demonstrated subnanomolar factor Xa binding Kis, modest to high selectivity versus other serine proteases, and good in vitro clotting activity. A small number of indoline fXa inhibitors were profiled in a dog pharmacokinetic model, one of which demonstrated pharmacokinetic parameters similar to that of clinical candidate razaxaban.

Nitrogen containing heterobicycles as factor Xa inhibitors

-

, (2008/06/13)

This invention relates generally to nitrogen containing heterobicycles of formulas A and B: which are inhibitors of trypsin-like serine protease enzymes, especially factor Xa, pharmaceutical compositions containing the same, and methods of using the same as anticoagulant agents for treatment and prevention of thromboembolic disorders.

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