tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinate

Base Information

• Chemical Name: tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinate
• CAS No.: 1354356-24-3
• Molecular Formula: C16H24BNO4
• Molecular Weight: 305.18
• Hs Code.: 2934999090
• Mol file: 1354356-24-3.mol

Synonyms:tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinate

Chemical Property of tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinate

Chemical Property:

• Boiling Point: 413.0±30.0 °C(Predicted)
• PKA: 1.83±0.12(Predicted)
• PSA: 57.65000
• Density: 1.07±0.1 g/cm3(Predicted)
• LogP: 2.33610
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Tert-Butyl5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Picolinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinate

There total 1 articles about tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 5-bromopyridine-2-carboxylate (845306-08-3) + bis(pinacol)diborane (73183-34-3) → tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carboxylate (1354356-24-3)

Guidance literature:

With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dimethyl sulfoxide; at 90 ℃; for 3h; Inert atmosphere;

Reference yield: 47.0%

tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carboxylate (1354356-24-3) + 1-bromo-4-(difluoromethoxy)-2-methylbenzene (1021172-76-8) → tert-butyl 5-(2-methyl-4-(difluoromethoxy)phenyl)picolinate

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In water; toluene; for 0.75h; Inert atmosphere; Reflux;

DOI:10.1016/j.ejmech.2021.114059

upstream raw materials:

tert-butyl 5-bromopyridine-2-carboxylate

bis(pinacol)diborane