21-Desacetyl AMcinonide

Base Information

• Chemical Name: 21-Desacetyl AMcinonide
• CAS No.: 55646-99-6
• Molecular Formula: C₂₆H₃₃FO₆
• Molecular Weight: 460.543
• Mol file: 55646-99-6.mol

Synonyms:21-Desacetyl AMcinonide;(11β,16α)-16,17-[Cyclopentylidenebis(oxy)]-9-fluoro-11,21-dihydroxypregna-1,4-diene-3,20-dione

Chemical Property of 21-Desacetyl AMcinonide

Chemical Property:

• PSA: 93.06000
• LogP: 2.95300
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

21-DesacetylAmcinonide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Amcinonide (A576150) analog as glucocorticoid receptor agonists for the treatment of inflammation and allergic conditions.

Technology Process of 21-Desacetyl AMcinonide

There total 1 articles about 21-Desacetyl AMcinonide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.4%

C21H26O6 (94088-91-2) + cyclopentanone (120-92-3) → C26H33FO6 (55646-99-6)

Guidance literature:

C₂₁H₂₆O₆; With hydrogen fluoride; In acetone; at -30 ℃; for 3h;

cyclopentanone; In acetone; at 0 ℃; for 3h; Temperature;

Reference yield: 97.1%

acetic anhydride (108-24-7) + C26H33FO6 (55646-99-6) → amcinonide

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 5h; Temperature;

upstream raw materials:

C₂₁H₂₆O₆

cyclopentanone

Refernces