94088-91-2

Basic information

• Product Name: 9beta,11beta-epoxy-16alpha,17,21-trihydroxypregna-1,4-diene-3,20-dione
• Synonyms: 9beta,11beta-epoxy-16alpha,17,21-trihydroxypregna-1,4-diene-3,20-dione;9β,11β-Epoxy-16α,17α,21-trihydroxypregna-1,4-diene-3,20-dione
• CAS NO: 94088-91-2
• Molecular Formula: C21H26O6
• Molecular Weight: 374.42754
• EINECS: 302-094-1
• Mol File: 94088-91-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 585.6°Cat760mmHg
• Flash Point: 208.2°C
• Appearance: /
• Density: 1.42g/cm³
• CAS DataBase Reference: 9beta,11beta-epoxy-16alpha,17,21-trihydroxypregna-1,4-diene-3,20-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 9beta,11beta-epoxy-16alpha,17,21-trihydroxypregna-1,4-diene-3,20-dione(94088-91-2)
• EPA Substance Registry System: 9beta,11beta-epoxy-16alpha,17,21-trihydroxypregna-1,4-diene-3,20-dione(94088-91-2)

Safety Data

• Hazardous Substances Data: 94088-91-2(Hazardous Substances Data)

Upstream product

• 91160-89-3 9α-bromo-11β,16α,17α,21-tetrahydroxypregnane-1,4-diene-3,20-dione-21-acetate 
• 77017-20-0 16α,17α,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione-21-acetate 
• 37413-91-5 2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate 

Relevant articles and documents

Preparation process of triamcinolone acetonide

The invention relates to a preparation process of triamcinolone acetonide. The triamcinolone acetonide is prepared by taking an intermediate III as a raw material. The preparation process comprises the following steps of: by taking a hydrofluoric acid-acetone mixed solvent as a solvent, slowly adding the intermediate III in a temperature range of 40 DEG C below zero to 30 DEG C below zero; after adding the raw material, performing a reaction for 4-8 hours; returning the temperature to 5 DEG C below zero to zero DEG C, and continuously performing a reaction for 10-30 min; after reaction, slowly adding the reaction liquid into a potassium carbonate solution; adjusting the PH value to 7.0-7.5; filtering and discharging the material; and drying the same to obtain triamcinolone acetonide. The preparation process shortens the production period, prevents use of a lot of high-matching acetone and is more environmentally friendly.