Technology Process of AKOS BAR-2451
There total 4 articles about AKOS BAR-2451 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium on activated charcoal; sodium carbonate;
In
methanol; water;
at 77.8 ℃;
for 5h;
Reagent/catalyst;
Inert atmosphere;
Large scale;
DOI:10.1021/op980079g
- Guidance literature:
-
Multi-step reaction with 2 steps
1: hydrogenchloride / water / 4 h / Heating
2: sodium carbonate; palladium on activated charcoal / methanol; water / 5 h / 77.8 °C / Inert atmosphere; Large scale
With
hydrogenchloride; palladium on activated charcoal; sodium carbonate;
In
methanol; water;
2: |Suzuki Coupling;
DOI:10.1021/op980079g
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / toluene / 20 h / 110 °C / Inert atmosphere
2: sodium carbonate; palladium on activated charcoal / methanol; water / 5 h / 77.8 °C / Inert atmosphere; Large scale
With
tris-(dibenzylideneacetone)dipalladium(0); palladium on activated charcoal; sodium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
methanol; water; toluene;
2: |Suzuki Coupling;
DOI:10.1021/op980079g
