Technology Process of SB-245570
There total 5 articles about SB-245570 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: hydrogenchloride / water / 4 h / Heating
2: sodium carbonate; palladium on activated charcoal / methanol; water / 5 h / 77.8 °C / Inert atmosphere; Large scale
3: 1,1'-carbonyldiimidazole / tetrahydrofuran
With
hydrogenchloride; palladium on activated charcoal; sodium carbonate; 1,1'-carbonyldiimidazole;
In
tetrahydrofuran; methanol; water;
2: |Suzuki Coupling;
DOI:10.1021/op980079g
- Guidance literature:
-
Multi-step reaction with 3 steps
1: tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / toluene / 20 h / 110 °C / Inert atmosphere
2: sodium carbonate; palladium on activated charcoal / methanol; water / 5 h / 77.8 °C / Inert atmosphere; Large scale
3: 1,1'-carbonyldiimidazole / tetrahydrofuran
With
tris-(dibenzylideneacetone)dipalladium(0); palladium on activated charcoal; sodium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1,1'-carbonyldiimidazole;
In
tetrahydrofuran; methanol; water; toluene;
2: |Suzuki Coupling;
DOI:10.1021/op980079g
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 0 - 20 °C / Inert atmosphere; Large scale
2: sodium carbonate; palladium on activated charcoal / methanol; water / 5 h / 77.8 °C / Inert atmosphere; Large scale
3: 1,1'-carbonyldiimidazole / tetrahydrofuran
With
palladium on activated charcoal; potassium tert-butylate; sodium carbonate; 1,1'-carbonyldiimidazole;
In
tetrahydrofuran; methanol; water;
2: |Suzuki Coupling;
DOI:10.1021/op980079g
