4-(3-AMINO-PROPYL)-1H-IMIDAZOL-2-YLAMINE 2HCL

Base Information

• Chemical Name: 4-(3-AMINO-PROPYL)-1H-IMIDAZOL-2-YLAMINE 2HCL
• CAS No.: 80822-62-4
• Molecular Formula: C6H14Cl2N4
• Molecular Weight: 213.10816
• Mol file: 80822-62-4.mol

Synonyms:4-(3-AMINO-PROPYL)-1H-IMIDAZOL-2-YLAMINE 2HCL

Chemical Property of 4-(3-AMINO-PROPYL)-1H-IMIDAZOL-2-YLAMINE 2HCL

Chemical Property:

• PSA: 80.72000
• LogP: 2.76870

Purity/Quality:

97% ^*data from raw suppliers

4-(3-AMINO-PROPYL)-1H-IMIDAZOL-2-YLAMINE DIHYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(3-AMINO-PROPYL)-1H-IMIDAZOL-2-YLAMINE 2HCL

There total 5 articles about 4-(3-AMINO-PROPYL)-1H-IMIDAZOL-2-YLAMINE 2HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

tert-butyl [4-(3-aminopropyl)-1H-imidazol-2-yl]carbamate (917919-57-4) → 4-(3-aminopropyl)-1H-imidazol-2-ylamine dihydrochloride (80822-62-4)

Guidance literature:

With hydrogenchloride; In ethanol; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.tet.2010.05.074

Reference yield: 42.0%

CYANAMID (420-04-2) + ornithine ethyl ester dihydrochloride (84772-29-2,94231-37-5) → 4-(3-aminopropyl)-1H-imidazol-2-ylamine dihydrochloride (80822-62-4)

Guidance literature:

ornithine ethyl ester dihydrochloride; With hydrogenchloride; sodium amalgam; In water; at 0 ℃; pH=1 - 3;

CYANAMID; With sodium hydroxide; In water; at 95 ℃; for 2h; pH=4.5;

DOI:10.1071/CH13346

Reference yield:

DL-ornithine hydrochloride (1069-31-4,36630-89-4) → 4-(3-aminopropyl)-1H-imidazol-2-ylamine dihydrochloride (80822-62-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / 8 h / 0 °C / Reflux

2.1: hydrogenchloride; sodium amalgam / water / 0 °C / pH 1 - 3

2.2: 2 h / 95 °C / pH 4.5

With hydrogenchloride; thionyl chloride; sodium amalgam; In water;

DOI:10.1071/CH13346

upstream raw materials:

CYANAMID

tert-butyl [4-(3-aminopropyl)-1H-imidazol-2-yl]carbamate

DL-ornithine hydrochloride

ornithine ethyl ester dihydrochloride

Downstream raw materials:

C₁₇H₁₇Br₂N₅O

C₁₇H₁₆Br₃N₅O

C₁₈H₁₉Br₂N₅O

C₁₉H₂₁Br₂N₅O₂