ethyl 4-hydroxy-5,7-dimethoxy-naphthalene-2-carboxylate

Base Information

Chemical Name:ethyl 4-hydroxy-5,7-dimethoxy-naphthalene-2-carboxylate
CAS No.:94002-68-3
Molecular Formula:C₁₅H₁₆O₅
Molecular Weight:276.289
Hs Code.:

Synonyms:2-Naphthalenecarboxylic acid, 4-hydroxy-5,7-diMethoxy-, ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 4-hydroxy-5,7-dimethoxy-naphthalene-2-carboxylate

Chemical Property:

Vapor Pressure:1.7E-09mmHg at 25°C
Boiling Point:471°C at 760 mmHg
Flash Point:176.9°C
PSA：64.99000
Density:1.231g/cm³
LogP:2.73930

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of ethyl 4-hydroxy-5,7-dimethoxy-naphthalene-2-carboxylate

There total 7 articles about ethyl 4-hydroxy-5,7-dimethoxy-naphthalene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 155816-92-5
ethyl 4-acetoxy-5,7-dimethoxy-2-naphthoate

: ethyl 3-acetyl-4-hydroxy-5,7-dimethoxy-2-naphthoate

: 94002-68-3
4-hydroxy-5,7-dimethoxy-[2]naphthoic acid ethyl ester

Guidance literature:: ethyl 4-acetoxy-5,7-dimethoxy-2-naphthoate; With boron trifluoride diacetate; In dichloromethane; for 0.5h; Reflux; Inert atmosphere;

With water; In dichloromethane; at 0 ℃;
DOI:10.1055/s-0031-1290429

Reference yield: 83.0%

: C₁₉H₂₆O₆

: 94002-68-3
4-hydroxy-5,7-dimethoxy-[2]naphthoic acid ethyl ester

Guidance literature:: With trifluoroacetic acid; at 1 ℃; Inert atmosphere; Reflux;
DOI:10.1021/acs.orglett.5b03202

Reference yield:

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 94002-68-3
4-hydroxy-5,7-dimethoxy-[2]naphthoic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 3 h / 0 °C

2.1: trifluoroacetic acid / dichloromethane / 10 h

3.1: sodium acetate / 0.17 h / 160 °C

4.1: boron trifluoride diacetate / dichloromethane / 0.5 h / Reflux; Inert atmosphere

4.2: 0 °C

With sodium acetate; boron trifluoride diacetate; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 1.1: Horner-Wadsworth-Emmons reaction / 4.1: Fries rearrangement;
DOI:10.1055/s-0031-1290429