(2s,3r)-2-amino-3-hydroxyhexanoic Acid

Base Information

Chemical Name:(2s,3r)-2-amino-3-hydroxyhexanoic Acid
CAS No.:10148-69-3
Molecular Formula:C₆H₁₃NO₃
Molecular Weight:147.174
Hs Code.:2922509090
DSSTox Substance ID:DTXSID10705271
Nikkaji Number:J970.847B
Wikidata:Q82638075
Mol file:10148-69-3.mol

Synonyms:(2s,3r)-2-amino-3-hydroxyhexanoic Acid;10148-69-3;(2S,3R)-3-HYDROXYNORLEUCINE;L-Norleucine, 3-hydroxy-, (3R)-;Threo-l-b-hydroxynorleucine;SCHEMBL720918;(3R)-3-Hydroxy-L-norleucine;DTXSID10705271;AKOS006327091;(2s,3r)-2-amino-3-hydroxyhexanoicAcid;A900812

Suppliers and Price of (2s,3r)-2-amino-3-hydroxyhexanoic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2S,3R)-3-Hydroxynorleucine
2.5mg
$ 90.00

Medical Isotopes, Inc.
(2S,3R)-3-Hydroxynorleucine
1 g
$ 550.00

Medical Isotopes, Inc.
(2S,3R)-3-Hydroxynorleucine
10 g
$ 1880.00

Crysdot
(2S,3R)-2-Amino-3-hydroxyhexanoicacid 97%
1g
$ 1580.00

Chemenu
(2S,3R)-2-Amino-3-hydroxyhexanoicacid 97%
1g
$ 1477.00

American Custom Chemicals Corporation
THREO-L-BETA-HYDROXYNORLEUCINE 95.00%
5MG
$ 501.45

Total 10 raw suppliers

Chemical Property of (2s,3r)-2-amino-3-hydroxyhexanoic Acid

Chemical Property:

Melting Point:226-227 °C
Boiling Point:328.6±32.0 °C(Predicted)
PKA:2.39±0.28(Predicted)
PSA：83.55000
Density:1.185±0.06 g/cm3(Predicted)
LogP:0.25960
Storage Temp.:Refrigerator
Solubility.:Water (Slightly)
XLogP3:-2.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:147.08954328
Heavy Atom Count:10
Complexity:116

Purity/Quality:

97% ^*data from raw suppliers

(2S,3R)-3-Hydroxynorleucine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCC(C(C(=O)O)N)O
Isomeric SMILES:CCC[C@H]([C@@H](C(=O)O)N)O
Uses (2S,3R)-3-Hydroxynorleucine is an analogue of DL-6-Hydroxy Norleucine (H948855) which is an intermediate for antiviral and antihypertensive drugs.

Technology Process of (2s,3r)-2-amino-3-hydroxyhexanoic Acid

There total 19 articles about (2s,3r)-2-amino-3-hydroxyhexanoic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 129274-25-5
(5S,6R)-3-(1-Hydroxy-butyl)-2-oxo-5,6-diphenyl-morpholine-4-carboxylic acid benzyl ester

: 2076-44-0,2076-55-3,10148-68-2,10148-69-3,34042-01-8,50730-80-8,52773-82-7,59286-25-8,59286-26-9,87585-08-8
L-erythro β-Hydroxynorleucine

Guidance literature:: With hydrogen; palladium dichloride; In tetrahydrofuran; ethanol; under 2068.6 Torr;
DOI:10.1016/S0040-4039(00)94638-0

Reference yield:

: (2S,3R)-3-Hydroxy-2-((S)-2-hydroxy-1-phenyl-ethylamino)-hexanoic acid methyl ester

: 10148-69-3
L-3-propylserine

Guidance literature:: With hydrogen; trifluoroacetic acid; palladium dihydroxide; In methanol; water; for 48h; under 3800 Torr;
DOI:10.1016/S0040-4020(98)00302-0

Reference yield:

: 123-72-8
butyraldehyde

: 56-40-6,18875-39-3,25718-94-9
glycine

: 10148-69-3
L-3-propylserine

: 10148-68-2
L-3-propylserine

Guidance literature:: With pyridoxal 5'-phosphate; L-threonine aldolase; In phosphate buffer; at 25 ℃; for 6h; Title compound not separated from byproducts.;
DOI:10.1016/j.tet.2007.06.013