D-valine dane salt

Base Information

• Chemical Name: D-valine dane salt
• CAS No.: 134841-35-3
• Molecular Formula: C₁₀H₁₆NO₄*K
• Molecular Weight: 253.34
• Mol file: 134841-35-3.mol

Synonyms:D-valine dane salt;(R)-3-[(1-Carboxy-2-methylpropyl)amino]-2-butenoic acid monomethyl ester monopotassium salt;(R)-Valine Dane salt

Chemical Property of D-valine dane salt

Chemical Property:

• Vapor Pressure: 1.9Pa at 25℃
• PSA: 78.46000
• Density: 1.29 at 20℃
• LogP: -0.18180

Purity/Quality:

99.9% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of D-valine dane salt

There total 1 articles about D-valine dane salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

D-Val-OH (640-68-6,25609-85-2,7004-03-7,921-10-8) + acetoacetic acid methyl ester (105-45-3) → N-(3-methoxy-1-methyl-3-oxo-1-propenyl)-R-valine, potassium salt (134841-35-3)

Guidance literature:

With potassium hydroxide; In isopropyl alcohol; for 2h; Heating / reflux;

Reference yield: 90.5%

N-(3-methoxy-1-methyl-3-oxo-1-propenyl)-R-valine, potassium salt (134841-35-3) + C26H43NO5S → [[2-[[(2R)-2-amino-3-methyl-1-oxobutyl]amino]-1,1-dimethylethyl]thio](3aS,4R,5S,6S,8R,9R,9aR,10R)-6-vinyltetrahydro-5-hydroxy-10-tetramethyl-1-oxo-3a,9-propanol-3aH-cyclopentadieno-cycloocten-8-yl ester hydrochloride

Guidance literature:

N-(3-methoxy-1-methyl-3-oxo-1-propenyl)-R-valine, potassium salt; With 4-methyl-morpholine; chloroformic acid ethyl ester; In tetrahydrofuran; ethanol; at 5 ℃; for 0.5h;

C₂₆H₄₃NO₅S; In tetrahydrofuran; ethanol; at 20 ℃; for 2h;

With hydrogenchloride; In water; ethyl acetate; for 0.5h; pH=1 - 1.2; Concentration;

upstream raw materials:

D-Val-OH

acetoacetic acid methyl ester

Refernces

• 1、 -. "Process for the preparation of pleuromutilins". Page/Page column 7. . Retrieved 2008/06/13.