TPRC3 Channel Inhibitor III, Pyr10

Base Information

Chemical Name:TPRC3 Channel Inhibitor III, Pyr10
CAS No.:1315323-00-2
Molecular Formula:C18H13F6N3O2S
Molecular Weight:449.37
Hs Code.:
European Community (EC) Number:808-921-7
Pharos Ligand ID:TXD2Q315ZLXX
ChEMBL ID:CHEMBL4460029
Mol file:1315323-00-2.mol

Synonyms:Pyr10;1315323-00-2;TPRC3 Channel Inhibitor III, Pyr10;Pyr-10;CHEMBL4460029;N-[4-[3,5-bis(trifluoromethyl)pyrazol-1-yl]phenyl]-4-methylbenzenesulfonamide;N-(4-(3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-4-methylbenzenesulfonamide;N-{4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-4-methylbenzenesulfonamide;SCHEMBL17328269;GTPL10282;BCP16468;EX-A3814;BDBM50519470;CS-5276;HY-19408;MS-28136;F85327;A922230;N-(4-(3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-4-methyl-benzenesulfonamide

Suppliers and Price of TPRC3 Channel Inhibitor III, Pyr10

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Tocris
Pyr10 ≥98%(HPLC)
50
$ 545.00

DC Chemicals
Pyr10 >98%
250 mg
$ 950.00

Crysdot
Pyr10 98+%
50mg
$ 270.00

Crysdot
Pyr10 98+%
10mg
$ 73.00

Crysdot
Pyr10 98+%
5mg
$ 46.00

ChemScene
Pyr10 97.52%
10mg
$ 108.00

ChemScene
Pyr10 97.52%
5mg
$ 66.00

ChemScene
Pyr10 97.52%
50mg
$ 432.00

Biorbyt Ltd
Pyr10
50 mg
$ 584.80

Biorbyt Ltd
Pyr10
10 mg
$ 210.80

Total 11 raw suppliers

Chemical Property of TPRC3 Channel Inhibitor III, Pyr10

Chemical Property:

Melting Point:105-107 °C
Boiling Point:470.1±55.0 °C(Predicted)
PKA:6.98±0.10(Predicted)
PSA：72.37000
Density:1.47±0.1 g/cm3(Predicted)
LogP:6.17290
XLogP3:4.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:4
Exact Mass:449.06326681
Heavy Atom Count:30
Complexity:678

Purity/Quality:

99%, ^*data from raw suppliers

Pyr10 ≥98%(HPLC) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)N3C(=CC(=N3)C(F)(F)F)C(F)(F)F

Technology Process of TPRC3 Channel Inhibitor III, Pyr10

There total 4 articles about TPRC3 Channel Inhibitor III, Pyr10 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 98-59-9
p-toluenesulfonyl chloride

: 123066-64-8
4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl] aniline

: 1315323-00-2
N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazole-1-yl)phenyl)-4-methylbenzenesulfonamide

Guidance literature:: With pyridine; In acetonitrile; at 100 ℃; for 0.0833333h; Microwave irradiation;
DOI:10.1021/jo2009824

Reference yield:

: 1694-30-0
1,1,1,5,5,5-hexafluoro-4-hydroxy-pent-3-en-2-one

: 1315323-00-2
N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazole-1-yl)phenyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / ethanol; water / 0.08 h / 160 °C / Microwave irradiation

2: palladium 10% on activated carbon; cyclohexene / ethanol / 0.08 h / 150 °C / Microwave irradiation

3: pyridine / acetonitrile / 0.08 h / 100 °C / Microwave irradiation

With pyridine; hydrogenchloride; palladium 10% on activated carbon; cyclohexene; In ethanol; water; acetonitrile;
DOI:10.1021/jo2009824

Reference yield:

: 636-99-7
4-nitrophenylhydrazine hydrochloride

: 1315323-00-2
N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazole-1-yl)phenyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / ethanol; water / 0.08 h / 160 °C / Microwave irradiation

2: palladium 10% on activated carbon; cyclohexene / ethanol / 0.08 h / 150 °C / Microwave irradiation

3: pyridine / acetonitrile / 0.08 h / 100 °C / Microwave irradiation

With pyridine; hydrogenchloride; palladium 10% on activated carbon; cyclohexene; In ethanol; water; acetonitrile;
DOI:10.1021/jo2009824