4-(3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl)phenylamine

Base Information

Chemical Name:4-(3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl)phenylamine
CAS No.:123066-64-8
Molecular Formula:C11H7F6N3
Molecular Weight:295.187
Hs Code.:2933199090
DSSTox Substance ID:DTXSID10372386
Wikidata:Q72447404
ChEMBL ID:CHEMBL1866277
Mol file:123066-64-8.mol

Synonyms:123066-64-8;4-(3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl)phenylamine;CRAC intermediate 2;4-[3,5-bis(trifluoromethyl)pyrazol-1-yl]aniline;4-(3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl)aniline;Benzenamine, 4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-;4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]aniline;4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)aniline;C11H7F6N3;CRACintermediate2;4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl] aniline;Maybridge1_007664;MLS000860231;SCHEMBL3277337;CHEMBL1866277;HMS563E08;4-(3,5-bis-(Trifluoromethyl)-1H-pyrazol-1-yl)phenylamine;DTXSID10372386;TQR0359;HMS2799F18;BCP23922;MFCD00220969;SEW 04192;AKOS015852979;CCG-248298;CS-3897;GS-4357;SB67400;NCGC00485880-01;HY-20588;SMR000461010;A890856;SR-01000004603;1(4'-Aminophenyl)-3,5-bis(trifluoromethyl)pyrazole;1-(4-aminophenyl)-3,5-bis(trifluoromethyl)pyrazole;SR-01000004603-1;1-(4'-aminophenyl)-3,5-bis(trifluoromethyl)pyrazole;4-[3,5-bis(trifluromethyl)-1H-pyrazol-1-yl]aniline;4-[3,5-di(trifluoromethyl)-1H-pyrazol-1-yl]aniline

Suppliers and Price of 4-(3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl)phenylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-(3,5-Bis(trifluoromethyl)-1h-pyrazol-1-yl)phenylamine
100mg
$ 155.00

Matrix Scientific
4-(3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl)phenylamine 95+%
1g
$ 798.00

Matrix Scientific
4-(3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl)phenylamine 95+%
250mg
$ 370.00

Crysdot
CRACintermediate2 98+%
1g
$ 229.00

Crysdot
CRACintermediate2 98+%
5g
$ 685.00

ChemScene
CRACintermediate2 99.96%
100mg
$ 550.00

ChemScene
CRACintermediate2 99.96%
50mg
$ 350.00

ChemScene
CRACintermediate2 99.96%
5mg
$ 80.00

ChemScene
CRACintermediate2 99.96%
10mg
$ 120.00

Chemenu
4-(3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl)phenylamine 98%
250mg
$ 143.00

Total 30 raw suppliers

Chemical Property of 4-(3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl)phenylamine

Chemical Property:

Vapor Pressure:0.00127mmHg at 25°C
Melting Point:140-142 °C
Refractive Index:1.505
Boiling Point:298.4°C at 760 mmHg
PKA:2.65±0.10(Predicted)
Flash Point:134.3°C
PSA：43.84000
Density:1.52 g/cm³
LogP:4.07330
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:1
Exact Mass:295.05441621
Heavy Atom Count:20
Complexity:334

Purity/Quality:

97% ^*data from raw suppliers

4-(3,5-Bis(trifluoromethyl)-1h-pyrazol-1-yl)phenylamine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1N)N2C(=CC(=N2)C(F)(F)F)C(F)(F)F

Technology Process of 4-(3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl)phenylamine

There total 6 articles about 4-(3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl)phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 123066-63-7
1-(4-nitrophenyl)-3,5-bis(trifluoromethyl)-1H-pyrazole

: 123066-64-8
4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl] aniline

Guidance literature:: With palladium 10% on activated carbon; cyclohexene; In ethanol; at 150 ℃; for 0.0833333h; Microwave irradiation;
DOI:10.1021/jo2009824

Reference yield:

: 1522-22-1
1,1,1,5,5,5-hexafluoroacetylacetone

: 123066-64-8
4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl] aniline

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / ethanol / Heating

2: H₂ / Pd/C / ethyl acetate

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate; 1: cyclocondensation / 2: Reduction;
DOI:10.1021/jm990615a

Reference yield:

: 100-16-3
4-nitrophenylhydrazone

: 123066-64-8
4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl] aniline

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / ethanol / Heating

2: H₂ / Pd/C / ethyl acetate

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate; 1: cyclocondensation / 2: Reduction;
DOI:10.1021/jm990615a