Tetrahydro-2H-pyran-4-carboxylic acid benzyl ester

Base Information

• Chemical Name: Tetrahydro-2H-pyran-4-carboxylic acid benzyl ester
• CAS No.: 871022-58-1
• Molecular Formula: C13H16O3
• Molecular Weight: 220.268
• Mol file: 871022-58-1.mol

Synonyms:Tetrahydro-2H-pyran-4-carboxylic acid benzyl ester

Chemical Property of Tetrahydro-2H-pyran-4-carboxylic acid benzyl ester

Chemical Property:

• PSA: 35.53000
• LogP: 2.15640

Purity/Quality:

99% ^*data from raw suppliers

Benzyltetrahydro-2H-pyran-4-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Tetrahydro-2H-pyran-4-carboxylic acid benzyl ester

There total 2 articles about Tetrahydro-2H-pyran-4-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tetrahydro-2H-pyran-4-carbonylchloride (40191-32-0) + benzyl alcohol (100-51-6,185532-71-2) → benzyl tetrahydro-2H-pyran-4-carboxylate (871022-58-1)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 13h;

Reference yield:

tetrahydro-2H-pyran-4-carboxylic acid (5337-03-1) → benzyl tetrahydro-2H-pyran-4-carboxylate (871022-58-1)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 2.5 h / Reflux

2: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice

With thionyl chloride; triethylamine; In dichloromethane;

Reference yield:

benzyl tetrahydro-2H-pyran-4-carboxylate (871022-58-1) → 4-methyltetrahydro-2H-pyran-4-carboxylic acid (233276-38-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 2.5 h / -78 - 0 °C

2.1: palladium on activated charcoal; hydrogen / methanol / 4 h / 2068.65 Torr

With palladium on activated charcoal; hydrogen; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane;

upstream raw materials:

tetrahydro-2H-pyran-4-carbonylchloride

benzyl alcohol

tetrahydro-2H-pyran-4-carboxylic acid

Downstream raw materials:

4-methyltetrahydro-2H-pyran-4-carboxylic acid