40191-32-0

Basic information

• Product Name: Tetrahydro-2H-pyran-4-carbonyl chloride
• Synonyms: TETRAHYDRO-2H-PYRAN-4-CARBONYL CHLORIDE;Tetrahydro-2H-pyrane-4-carbonylchloride;2H-Pyran-4-carbonyl chloride, tetrahydro- (9CI);Tetrahydro-2H-Pyran-4-Carbonyl;Tetrahydro-2H-pyran-4-carbonyl chloride 97%;Tetrahydro-2H-pyran-4-carbonyl chloride ,97%;4-(Chlorocarbonyl)tetrahydro-2H-pyran;2H-Pyran-4-carbonyl chloride, tetrahydro-
• CAS NO: 40191-32-0
• Molecular Formula: C₆H₉ClO₂
• Molecular Weight: 148.59
• EINECS: 245-896-9
• Product Categories: ACIDHALIDE
• Mol File: 40191-32-0.mol
• Article Data: 52

Chemical Properties

• Boiling Point: 50 °C
• Flash Point: 71.8ºC
• Appearance: /
• Density: 1.201g/cm3
• Vapor Pressure: 0.416mmHg at 25°C
• Refractive Index: 1.463
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: Tetrahydro-2H-pyran-4-carbonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: Tetrahydro-2H-pyran-4-carbonyl chloride(40191-32-0)
• EPA Substance Registry System: Tetrahydro-2H-pyran-4-carbonyl chloride(40191-32-0)

Safety Data

• Hazard Codes: Xi,C
• Statements: 14-20/21/22-29-34-36-52/53
• Safety Statements: 23-24/25-36/37/39-45-26-61
• RIDADR: 3265
• HazardClass: IRRITANT
• Hazardous Substances Data: 40191-32-0(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to light yellow liquid

InChI:InChI=1/C6H9ClO2/c7-6(8)5-1-3-9-4-2-5/h5H,1-4H2

Upstream product

• 5382-77-4 tetrahydro-pyran-4,4-dicarboxylic acid diethyl ester 
• 5337-04-2 tetrahydro-4H-pyran-4,4-dicarboxylic acid 
• 101765-10-0 tetrahydro-4-(methoxymethylene)-2H-pyran 
• 50675-18-8 3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 5337-03-1 tetrahydro-2H-pyran-4-carboxylic acid 

Downstream Products

• 110238-91-0 tetrahydropyran-4-carboxylic acid methyl ester 
• 96835-17-5 ethyl tetrahydro-2H-pyran-4-carboxylate 
• 639468-72-7 phenyl(tetrahydro-2H-pyran-4-yl)methanone 
• 137052-08-5 1-(tetrahydro-2H-pyran-4-yl)ethan-1-one 
• 7464-18-8 1-(tetrahydro-2H-pyran-4-yl)propan-1-one 
• 50675-18-8 3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde 
• 344329-76-6 tetrahydro-pyran-4-carboxylic acid amide 
• 1800345-36-1 (S)-(tetrahydro-2H-pyran-4-yl)(phenyl)methanol 
• 1800345-36-1 (R)-(tetrahydro-2H-pyran-4-yl)(phenyl)methanol 
• 216087-92-2 rac-(tetrahydro-2H-pyran-4-yl)(phenyl)methanol 
• 195503-45-8 N-methyl-N-phenyl-6-oxa-1-azaspiro[2.5]oct-1-en-2-amine 
• 195503-54-9 4-(2-Benzyloxycarbonylamino-2-methyl-propionylamino)-tetrahydro-pyran-4-carboxylic acid 
• 195503-53-8 {1-Methyl-1-[4-(methyl-phenyl-carbamoyl)-tetrahydro-pyran-4-ylcarbamoyl]-ethyl}-carbamic acid benzyl ester 
• 195503-55-0 (1-Methyl-1-{4-[1-methyl-1-(methyl-phenyl-carbamoyl)-ethylcarbamoyl]-tetrahydro-pyran-4-ylcarbamoyl}-ethyl)-carbamic acid benzyl ester 

Relevant articles and documents

Fluorinated Sulfinates as Source of Alkyl Radicals in the Photo-Enantiocontrolled β-Functionalization of Enals

The generation of sulfonyl radicals has long been known as a flexible strategy in a wide range of different sulfonylative transformations. Meanwhile their use in alkylation processes has been somehow limited due to their inherent difficulty in evolving to less-stable radicals after sulfur dioxide extrusion. Herein we report a convenient strategy that involves gem-difluorinated sulfinates as an “upgrading-mask”, allowing these precursors to decompose into their corresponding alkyl radicals. The electron–donor character of sulfinates in the formation of an electron donor–acceptor (EDA) complex with transient iminium ions is displayed, achieving the first example of a stereocontrolled light-driven insertion of gem-difluoro derivatives into unsaturated aldehydes. This methodology is compatible with flow conditions, maintaining identical levels of enantiocontrol.

Derivatives of Napabucasin and pharmaceutical application thereof

The invention relates to derivatives of Napabucasin, and a pharmaceutical application thereof. The structure of the derivatives conforms to the general formula (I), and the water solubility of most of the compounds is obviously higher than that of Napabucasin. The compounds and pharmaceutically acceptable salts thereof can be used for preparing antitumor drugs, and the cell inhibition activity of most of the compounds is obviously superior to that of Napabucasin. Meanwhile, experiments show that the compounds have extremely high helicobacter pylori and fungal activity resistance and can be used for preparing drugs for resisting helicobacter pylori and fungal infection.

Visible-Light-Assisted Gold-Catalyzed Fluoroarylation of Allenoates

A strategically novel synthetic method for the fluoroarylation of allenic ester was developed that enables the expedient construction of a host of β-fluoroalkyl-containing cinnamate derivatives. The reaction proceeds through visible-light-promoted gold redox catalysis, occurs smoothly under very mild reaction conditions, accommodates a large variety of functional groups, and more importantly allows the incorporation of fluorine and aryl groups with excellent regio- and stereoselectivity. The concomitant activation mode for both the allene motif and the hydrogen fluoride is key for the success of the reaction.