C-(1H-INDOL-2-YL)-METHYLAMINE HYDROCHLORIDE

Base Information

• Chemical Name: C-(1H-INDOL-2-YL)-METHYLAMINE HYDROCHLORIDE
• CAS No.: 1159692-99-5
• Molecular Formula: C₉H₁₀N₂*ClH
• Molecular Weight: 182.653
• Mol file: 1159692-99-5.mol

Synonyms:C-(1H-INDOL-2-YL)-METHYLAMINE HYDROCHLORIDE;(1H-Indol-2-yl)methanamine hydrochloride

Chemical Property of C-(1H-INDOL-2-YL)-METHYLAMINE HYDROCHLORIDE

Chemical Property:

• PSA: 41.81000
• LogP: 3.12890

Purity/Quality:

98% ^*data from raw suppliers

(1H-Indol-2-ylmethyl)amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C-(1H-INDOL-2-YL)-METHYLAMINE HYDROCHLORIDE

There total 3 articles about C-(1H-INDOL-2-YL)-METHYLAMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

methyl 5-(2-aminobenzyl)oxazole-4-carboxylate → (1H-indol-2-yl)methanaminium chloride (1159692-99-5)

Guidance literature:

With hydrogenchloride; In methanol; for 5h; Reflux;

DOI:10.1016/j.tetlet.2014.11.015

Reference yield:

2-(2-nitrophenyl)acetic acid (3740-52-1) → (1H-indol-2-yl)methanaminium chloride (1159692-99-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 3 h / 20 °C

1.2: 20 °C

2.1: palladium on activated charcoal; cyclohexene / methanol / 0.05 h / 95 °C / Microwave irradiation; Sealed tube

3.1: hydrogenchloride / methanol / 5 h / Reflux

With hydrogenchloride; palladium on activated charcoal; 1,1'-carbonyldiimidazole; cyclohexene; In tetrahydrofuran; methanol;

DOI:10.1016/j.tetlet.2014.11.015

Reference yield:

methyl 5-(2-nitrobenzyl)oxazole-4-carboxylate → (1H-indol-2-yl)methanaminium chloride (1159692-99-5)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium on activated charcoal; cyclohexene / methanol / 0.05 h / 95 °C / Microwave irradiation; Sealed tube

2: hydrogenchloride / methanol / 5 h / Reflux

With hydrogenchloride; palladium on activated charcoal; cyclohexene; In methanol;

DOI:10.1016/j.tetlet.2014.11.015

upstream raw materials:

2-(2-nitrophenyl)acetic acid

Refernces