ethyl 4-(acetyloxy)-6-chloro-5,8-dimethoxynaphthalene-2-carboxylate

Base Information

• Chemical Name: ethyl 4-(acetyloxy)-6-chloro-5,8-dimethoxynaphthalene-2-carboxylate
• CAS No.: 124010-11-3
• Molecular Formula: C17H17ClO6
• Molecular Weight: 352.771
• Mol file: 124010-11-3.mol

Synonyms:2-Naphthalenecarboxylic acid, 4-(acetyloxy)-6-chloro-5,8-diMethoxy-, ethyl ester

Chemical Property of ethyl 4-(acetyloxy)-6-chloro-5,8-dimethoxynaphthalene-2-carboxylate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 501.214°C at 760 mmHg
• Flash Point: 191.971°C
• Density: 1.28g/cm³

Purity/Quality:

99% ，98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 4-(acetyloxy)-6-chloro-5,8-dimethoxynaphthalene-2-carboxylate

There total 11 articles about ethyl 4-(acetyloxy)-6-chloro-5,8-dimethoxynaphthalene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

acetic anhydride (108-24-7) + 3-Carbethoxy-4-(4-chloro-2,5-dimethoxyphenyl)-3-butenoic acid (124010-10-2) → Ethyl 4-(acetyloxy)-6-chloro-5,8-dimethoxy-2-naphthalenecarboxylate (124010-11-3)

Guidance literature:

With sodium acetate; at 140 ℃; for 3h;

DOI:10.1021/jo00079a042

Reference yield: 68.0%

sodium acetate (127-09-3) + 3-Carbethoxy-4-(4-chloro-2,5-dimethoxyphenyl)-3-butenoic acid (124010-10-2) → Ethyl 4-(acetyloxy)-6-chloro-5,8-dimethoxy-2-naphthalenecarboxylate (124010-11-3)

Guidance literature:

With acetic anhydride;

DOI:10.1016/S0040-4039(00)72715-8

Reference yield: 60.0%

(Z)-4-(4-chloro-2,5-dimethoxyphenyl)-3-(ethoxycarbonyl)but-3-enoic acid + acetic anhydride (108-24-7) → Ethyl 4-(acetyloxy)-6-chloro-5,8-dimethoxy-2-naphthalenecarboxylate (124010-11-3)

Guidance literature:

With sodium acetate; for 1h; Reflux; Inert atmosphere;

DOI:10.1016/j.bmcl.2016.11.029

upstream raw materials:

sodium acetate

3-Carbethoxy-4-(4-chloro-2,5-dimethoxyphenyl)-3-butenoic acid

acetic anhydride

2-chloro-1,4-dimethoxybenzene

Downstream raw materials:

6-Chloro-4-hydroxy-5,8-dimethoxy-naphthalene-2-carboxylic acid ethyl ester

citreorosein

1,8-dihydroxy-3-hydroxymethyl-6-methoxy-anthraquinone

1,8-dihydroxy-3-hydroxymethyl-9,10-anthracenedione