4-AMINO-N-PYRIDIN-3-YLBENZAMIDE

Base Information

• Chemical Name: 4-AMINO-N-PYRIDIN-3-YLBENZAMIDE
• CAS No.: 13160-59-3
• Molecular Formula: C12H11N3O
• Molecular Weight: 213.239
• Hs Code.: 2933399090
• Mol file: 13160-59-3.mol

Synonyms:4-AMINO-N-PYRIDIN-3-YLBENZAMIDE;4-AMINO-N-3-PYRIDINYLBENZAMIDE;AKOS BBV-011304;4-amino-N-3-pyridinylbenzamide(SALTDATA: FREE)

Chemical Property of 4-AMINO-N-PYRIDIN-3-YLBENZAMIDE

Chemical Property:

• Vapor Pressure: 7.29E-05mmHg at 25°C
• Boiling Point: 342.9°C at 760 mmHg
• Flash Point: 161.2°C
• PSA: 68.01000
• Density: 1.301g/cm³
• LogP: 2.57030

Purity/Quality:

97% ^*data from raw suppliers

4-Amino-N-(pyridin-3-yl)benzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-AMINO-N-PYRIDIN-3-YLBENZAMIDE

There total 5 articles about 4-AMINO-N-PYRIDIN-3-YLBENZAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-nitro-N-(pyridin-3-yl)benzamide (13313-18-3) → 4-amino-N-pyridin-3-yl-benzamide (13160-59-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; at 25 ℃; for 5h; under 2280 Torr;

DOI:10.1016/0040-4039(95)00815-T

Reference yield: 85.0%

C17H19N3O3 (1326565-88-1) → 4-amino-N-pyridin-3-yl-benzamide (13160-59-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 25 ℃; for 6h;

DOI:10.1016/j.bmcl.2013.12.062

Reference yield:

pyridin-3-ylamine (462-08-8) → 4-amino-N-pyridin-3-yl-benzamide (13160-59-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 25 - 50 °C

2: hydrogenchloride / 1,4-dioxane / 6 h / 25 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; HATU; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2013.12.062

upstream raw materials:

4-nitro-N-(pyridin-3-yl)benzamide

C₁₇H₁₉N₃O₃

pyridin-3-ylamine

4-(N-tert-butoxycarbonyl)aminobenzoic acid

Downstream raw materials:

4-({[4-(3-ethyl-7-morpholin-4-yl-3H-[1,2,3]triazolo[4,5-d]pyrimidin-5-yl)phenyl]carbamoyl}amino)-N-pyridin-3-ylbenzamide

C₁₉H₁₅N₃O₂

C₂₀H₁₇N₃O₂

C₁₉H₁₄ClN₃O₂

Refernces

• 1、 Dragovich, Peter S.,Zhao, Guiling,Baumeister, Timm,Bravo, Brandon,Giannetti, Anthony M.,Ho, Yen-Ching,Hua, Rongbao,Li, Guangkun,Liang, Xiaorong,Ma, Xiaolei,O'Brien, Thomas,Oh, Angela,Skelton, Nicholas J.,Wang, Chengcheng,Wang, Weiru,Wang, Yunli,Xiao, Yang,Yuen, Po-Wai,Zak, Mark,Zhao, Qiang,Zheng, Xiaozhang. "Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)". . p. 954 - 962. Retrieved 2014/02/14.