8-broMo-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine

Base Information

• Chemical Name: 8-broMo-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine
• CAS No.: 1215074-47-7
• Molecular Formula: C9H10BrNO
• Molecular Weight: 228.0858
• Hs Code.: 2934999090
• Mol file: 1215074-47-7.mol

Synonyms:8-broMo-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine;1,4-Benzoxazepine, 8-broMo-2,3,4,5-tetrahydro-

Chemical Property of 8-broMo-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine

Chemical Property:

• PSA: 21.26000
• LogP: 2.25990
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

8-Bromo-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-broMo-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine

There total 4 articles about 8-broMo-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

8-bromo-3,4-dihydro-2H-benzo[f][1,4]oxazepin-5-one (1396777-41-5) → 8-bromo-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine (1215074-47-7)

Guidance literature:

With borane-THF; In tetrahydrofuran; at 0 - 70 ℃;

Reference yield:

methyl 2-(2-((tert-butoxycarbonyl)amino)ethoxy)-4-bromobenzoate → 8-bromo-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine (1215074-47-7)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 20 °C

2: toluene / Reflux

3: borane-THF / tetrahydrofuran / 0 - 70 °C

With borane-THF; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

4-bromo-2-Hydroxybenzoic Acid Methylester (22717-56-2) → 8-bromo-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine (1215074-47-7)

Guidance literature:

Multi-step reaction with 4 steps

1: di-tert-butyl-diazodicarboxylate; triphenylphosphine / toluene / 3 h / 60 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 20 °C

3: toluene / Reflux

4: borane-THF / tetrahydrofuran / 0 - 70 °C

With borane-THF; di-tert-butyl-diazodicarboxylate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; toluene;

upstream raw materials:

4-bromo-2-Hydroxybenzoic Acid Methylester

8-bromo-3,4-dihydro-2H-benzo[f][1,4]oxazepin-5-one

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