Technology Process of C8H16Cl3N.ClH
There total 21 articles about C8H16Cl3N.ClH which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: (S)-BINAPO / Pd2dba3*CHCl3 / tetrahydrofuran / 18 h / Ambient temperature
2: 83 percent / FeCl3*SiO2 / acetone / Ambient temperature
3: 59 percent / 4 Angstroem molecular sieves / 230 - 240 °C
4: 98 percent / pyridine
5: 86 percent / SeO2 / dioxane / Heating
6: 1.) Ms2O, Et3N / 2.) 0 deg C
7: 1.) Na*C10H8, 3.) K2CO3 / 1.) THF, -95 deg C, 2.) MeCN, reflux, 3.) MeOH
With
pyridine; selenium(IV) oxide; 4 A molecular sieve; Na*C10H8; silica gel; iron(III) chloride; potassium carbonate; triethylamine; (S)-1,1'-binaphthalene-2,2'-diylbis(diphenylphosphine oxide); Methanesulfonic anhydride;
tris(dibenzylideneacetone)dipalladium(0) chloroform complex;
In
tetrahydrofuran; 1,4-dioxane; acetone;
DOI:10.1021/jo9815249
- Guidance literature:
-
Multi-step reaction with 7 steps
1: NaH, (S)-BINAPO / Pd2dba3*CHCl3 / tetrahydrofuran / 48 h / -20 °C / other solvents
2: 83 percent / FeCl3*SiO2 / acetone / Ambient temperature
3: 59 percent / 4 Angstroem molecular sieves / 230 - 240 °C
4: 98 percent / pyridine
5: 86 percent / SeO2 / dioxane / Heating
6: 1.) Ms2O, Et3N / 2.) 0 deg C
7: 1.) Na*C10H8, 3.) K2CO3 / 1.) THF, -95 deg C, 2.) MeCN, reflux, 3.) MeOH
With
pyridine; selenium(IV) oxide; 4 A molecular sieve; Na*C10H8; silica gel; iron(III) chloride; sodium hydride; potassium carbonate; triethylamine; (S)-1,1'-binaphthalene-2,2'-diylbis(diphenylphosphine oxide); Methanesulfonic anhydride;
tris(dibenzylideneacetone)dipalladium(0) chloroform complex;
In
tetrahydrofuran; 1,4-dioxane; acetone;
DOI:10.1021/jo9815249
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 59 percent / 4 Angstroem molecular sieves / 230 - 240 °C
2: 98 percent / pyridine
3: 86 percent / SeO2 / dioxane / Heating
4: 1.) Ms2O, Et3N / 2.) 0 deg C
5: 1.) Na*C10H8, 3.) K2CO3 / 1.) THF, -95 deg C, 2.) MeCN, reflux, 3.) MeOH
With
pyridine; selenium(IV) oxide; 4 A molecular sieve; Na*C10H8; potassium carbonate; triethylamine; Methanesulfonic anhydride;
In
1,4-dioxane;
DOI:10.1021/jo9815249
