Lee011 intermediate

Base Information

Chemical Name:Lee011 intermediate
CAS No.:1374639-76-5
Molecular Formula:C12H14ClN3O
Molecular Weight:251.71
Hs Code.:
Mol file:1374639-76-5.mol

Synonyms:Lee011 intermediate;3-(2-chloro-4-(cyclopentylamino)pyrimidin-5-yl)prop-2-yn-1-ol;2-Propyn-1-ol, 3-[2-chloro-4-(cyclopentylamino)-5-pyrimidinyl]-;3-[2-Chloro-4-(cyclopentylamino)-5-pyrimidinyl]-2-propyn-1-ol

Suppliers and Price of Lee011 intermediate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-[2-Chloro-4-(cyclopentylamino)-5-pyrimidinyl]-2-propyn-1-ol
1g
$ 250.00

TRC
3-[2-Chloro-4-(cyclopentylamino)-5-pyrimidinyl]-2-propyn-1-ol
250mg
$ 110.00

TRC
3-[2-Chloro-4-(cyclopentylamino)-5-pyrimidinyl]-2-propyn-1-ol
25g
$ 440.00

ChemScene
3-[2-Chloro-4-(cyclopentylamino)-5-pyrimidinyl]-2-propyn-1-ol
25g
$ 790.00

ChemScene
3-[2-Chloro-4-(cyclopentylamino)-5-pyrimidinyl]-2-propyn-1-ol
10g
$ 650.00

ChemScene
3-[2-Chloro-4-(cyclopentylamino)-5-pyrimidinyl]-2-propyn-1-ol
5g
$ 430.00

Total 24 raw suppliers

Chemical Property of Lee011 intermediate

Chemical Property:

Boiling Point:488.3±40.0 °C(Predicted)
PKA:13.33±0.10(Predicted)
PSA：58.04000
Density:1.33±0.1 g/cm3(Predicted)
LogP:1.90130

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-[2-Chloro-4-(cyclopentylamino)-5-pyrimidinyl]-2-propyn-1-ol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 3-[2-Chloro-4-(cyclopentylamino)-5-pyrimidinyl]-2-propyn-1-ol is a useful reagent for preparation of salts of 7-?cyclopentyl-?2-?(5-?piperazin-?1-?yl-?pyridin-?2-?ylamino)?-?7H-?pyrrolo[2,?3-?d]?pyrimidine-?6-?carboxylic acid dimethylamide.

Technology Process of Lee011 intermediate

There total 3 articles about Lee011 intermediate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.5%

: 733039-20-8
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

: 107-19-7
propargyl alcohol

: 1374639-76-5
3-(2-chloro-4-(cyclopentylamino)pyrimidin-5-yl)prop-2-yn-1-ol

Guidance literature:: 5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine; With copper(l) iodide; palladium on activated charcoal; N-ethyl-N,N-diisopropylamine; bis[2-(diphenylphosphino)phenyl] ether; In tetrahydrofuran; at 20 ℃; for 0.166667h; Inert atmosphere;

propargyl alcohol; In tetrahydrofuran; for 5.5h; Reflux;

With bis[2-(diphenylphosphino)phenyl] ether; for 4h; Reflux;

Reference yield: 65.9%

: 733039-20-8
5-bromo-2-chloro-N-cyclopentylaminopyrimidine-4-amine

: 6175-54-8
hydroxy-1-propyne

: 1374639-76-5
3-(2-chloro-4-(cyclopentylamino)pyrimidin-5-yl)prop-2-yn-1-ol

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; tetrabutyl ammonium fluoride; In tetrahydrofuran; at 70 ℃; for 5h;

Reference yield:

: 1003-03-8
Cyclopentamine

: 1374639-76-5
3-(2-chloro-4-(cyclopentylamino)pyrimidin-5-yl)prop-2-yn-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / ethyl acetate / 7 h / 18 - 40 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / bis-triphenylphosphine-palladium(II) chloride / water; tetrahydrofuran / 2 h / 25 - 67 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; water; ethyl acetate;