(2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidin-6-yl)Methanol

Base Information

• Chemical Name: (2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidin-6-yl)Methanol
• CAS No.: 1374639-77-6
• Molecular Formula: C12H14ClN3O
• Molecular Weight: 251.71206
• Mol file: 1374639-77-6.mol

Synonyms:(2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidin-6-yl)Methanol;2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidine-6-Methanol;7H-Pyrrolo[2,3-d]pyrimidine-6-methanol, 2-chloro-7-cyclopentyl-

Chemical Property of (2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidin-6-yl)Methanol

Chemical Property:

• PKA: 14.09±0.10(Predicted)
• PSA: 50.94000
• Density: 1.50±0.1 g/cm3(Predicted)
• LogP: 2.69210
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidin-6-yl)Methanol

There total 1 articles about (2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyriMidin-6-yl)Methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.5%

3-(2-chloro-4-(cyclopentylamino)pyrimidin-5-yl)prop-2-yn-1-ol (1374639-76-5) → (2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanol (1374639-77-6)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 70 ℃; for 12h;

Reference yield: 75.1%

(2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanol (1374639-77-6) + dimethyl amine (124-40-3) → 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide (1211443-61-6)

Guidance literature:

(2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanol; dimethyl amine; With sodium cyanide; In N,N-dimethyl-formamide; at 20 ℃; for 0.0666667h;

With manganese(IV) oxide; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield: 72.0%

(2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)methanol (1374639-77-6) → 2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbaldehyde (1211443-55-8)

Guidance literature:

With manganese(IV) oxide; In tetrahydrofuran; at 10 - 29 ℃; for 2h; Inert atmosphere;

DOI:10.2174/1386207320666170816141351

upstream raw materials:

3-(2-chloro-4-(cyclopentylamino)pyrimidin-5-yl)prop-2-yn-1-ol

Downstream raw materials:

2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide

N,N‐dimethyl‐7‐cyclopentyl‐2‐{[5‐(4-tert-butoxycarbonylpiperazin‐1‐yl)pyridin‐2‐yl]amino}‐7H‐pyrrolo[2,3‐d]pyrimidine‐6‐carboxamide

7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide succinate

2-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidine-6-carbaldehyde

Refernces

• 1、 -. "PROCESS FOR PREPARATION OF RIBOCICLIB, ITS ACID ADDITION SALTS". Page/Page column 20. . Retrieved 2018/04/13.
• 2、 -. "SALT(S) OF 7-CYCLOPENTYL-2-(5-PIPERAZIN-1-YL-PYRIDIN-2-YLAMINO)-7H-PYRROLO[2,3-D]PYRIMIDINE-6-CARBOXYLIC ACID DIMETHYLAMIDE AND PROCESSES OF MAKING THEREOF". Page/Page column 7. . Retrieved 2012/05/20.