Boronic acid, B-[4-[[4-[(E)-[1-[(4-fluorophenyl)Methyl]-2,5-dioxo-3-pyrrolidinylidene]Methyl]phenoxy]Methyl]phenyl]-

Base Information

Chemical Name:Boronic acid, B-[4-[[4-[(E)-[1-[(4-fluorophenyl)Methyl]-2,5-dioxo-3-pyrrolidinylidene]Methyl]phenoxy]Methyl]phenyl]-
CAS No.:1312201-54-9
Molecular Formula:C₂₅H₂₁BFNO₅
Molecular Weight:445.255
Hs Code.:
Mol file:1312201-54-9.mol

Synonyms:Boronic acid, B-[4-[[4-[(E)-[1-[(4-fluorophenyl)Methyl]-2,5-dioxo-3-pyrrolidinylidene]Methyl]phenoxy]Methyl]phenyl]-;(E)-4-((4-((1-(4-fluorobenzyl)-2,5-dioxopyrrolidin-3-ylidene)methyl)phenoxy)methyl)phenylboronic acid

Suppliers and Price of Boronic acid, B-[4-[[4-[(E)-[1-[(4-fluorophenyl)Methyl]-2,5-dioxo-3-pyrrolidinylidene]Methyl]phenoxy]Methyl]phenyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Boronic acid, B-[4-[[4-[(E)-[1-[(4-fluorophenyl)Methyl]-2,5-dioxo-3-pyrrolidinylidene]Methyl]phenoxy]Methyl]phenyl]-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Boronic acid, B-[4-[[4-[(E)-[1-[(4-fluorophenyl)Methyl]-2,5-dioxo-3-pyrrolidinylidene]Methyl]phenoxy]Methyl]phenyl]-

There total 6 articles about Boronic acid, B-[4-[[4-[(E)-[1-[(4-fluorophenyl)Methyl]-2,5-dioxo-3-pyrrolidinylidene]Methyl]phenoxy]Methyl]phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1312201-52-7
(E)-(4-((4-((2,5-dioxopyrrolidin-3-ylidene)methyl)phenoxy)methyl)phenyl)boronic acid

: 459-46-1
4-Fluorobenzyl bromide

: 1312201-54-9
(E)-(4-((4-((1-(4-fluorobenzyl)-2,5-dioxopyrrolidin-3-ylidene)methyl)phenoxy)methyl)phenyl)boronic acid

Guidance literature:: (E)-(4-((4-((2,5-dioxopyrrolidin-3-ylidene)methyl)phenoxy)methyl)phenyl)boronic acid; 4-Fluorobenzyl bromide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 4h;

With potassium carbonate; In N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm200310q

Reference yield:

: 1312201-10-7
4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)benzaldehyde

: 1312201-54-9
(E)-(4-((4-((1-(4-fluorobenzyl)-2,5-dioxopyrrolidin-3-ylidene)methyl)phenoxy)methyl)phenyl)boronic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium periodate / tetrahydrofuran; water / 0.5 h

1.2: 4 h

2.1: triphenylphosphine / methanol / 1 h / 69.84 °C

2.2: Heating

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 4 h

With sodium periodate; sodium hydride; triphenylphosphine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm200310q

Reference yield:

: 149833-95-4
4-((4-bromobenzyl)oxy)benzaldehyde

: 1312201-54-9
(E)-(4-((4-((1-(4-fluorobenzyl)-2,5-dioxopyrrolidin-3-ylidene)methyl)phenoxy)methyl)phenyl)boronic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 18 h / 79.84 °C

2.1: sodium periodate / tetrahydrofuran; water / 0.5 h

2.2: 4 h

3.1: triphenylphosphine / methanol / 1 h / 69.84 °C

3.2: Heating

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 4 h

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium periodate; potassium acetate; sodium hydride; triphenylphosphine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; mineral oil; 1.1: Suzuki coupling;
DOI:10.1021/jm200310q