SEP-0372814

Base Information

• Chemical Name: SEP-0372814
• CAS No.: 1516895-53-6
• Molecular Formula: C21H19N7
• Molecular Weight: 369.42
• Mol file: 1516895-53-6.mol

Synonyms:SEP-0372814;rel-2-[(1R,2R)-2-(5,8-Dimethyl[1,2,4]triazolo[1,5-a]pyrazin-2-yl)cyclopropyl]-3-methylimidazo[2,1-f][1,6]naphthyridine

Chemical Property of SEP-0372814

Chemical Property:

• PKA: 5.38±0.50(Predicted)
• PSA: 73.27000
• Density: 1.52±0.1 g/cm3(Predicted)
• LogP: 3.51650
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

SEP-0372814 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of SEP-0372814

There total 21 articles about SEP-0372814 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

trans-2-bromo-1-(2-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)cyclopropyl)propan-1-one + 1,6-naphthyridin-5-amine (55570-60-0) → trans-2-(2-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)cyclopropyl)-3-methylimidazo[2,1-f][1,6]naphthyridine (1516895-53-6)

Guidance literature:

With sodium hydrogencarbonate; In ethanol; at 80 ℃;

Reference yield:

trans-2-(2-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)cyclopropyl)-3-methylimidazo[2,1-f][1,6]naphthyridine (1516895-53-6) → 3-methyl-2-((1S,2S)-2-(quinolin-2-yl)cyclopropyl)-3H-imidazo[4,5-f]quinoline (1516896-09-5,1516895-53-6) + C21H19N7 (1516896-06-2)

Guidance literature:

With isopropylamine; In methanol; acetonitrile; Resolution of racemate;

Reference yield:

trans-1-(2-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)cyclopropyl)propan-1-one → trans-2-(2-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)cyclopropyl)-3-methylimidazo[2,1-f][1,6]naphthyridine (1516895-53-6)

Guidance literature:

Multi-step reaction with 2 steps

1: phenyltrimethylammonium tribromide / tetrahydrofuran / 40 °C

2: sodium hydrogencarbonate / ethanol / 80 °C

With phenyltrimethylammonium tribromide; sodium hydrogencarbonate; In tetrahydrofuran; ethanol;

upstream raw materials:

1,6-naphthyridin-5-amine

5-chloro-[1,6]naphthyridine

1,6-naphthyridine-5(6H)-one

5-azido-1,6-naphthyridine

Downstream raw materials:

3-methyl-2-((1S,2S)-2-(quinolin-2-yl)cyclopropyl)-3H-imidazo[4,5-f]quinoline

C₂₁H₁₉N₇