3-Methoxy-2-methoxycarbonylbenzeneoctanoic acid methyl ester

Base Information

• Chemical Name: 3-Methoxy-2-methoxycarbonylbenzeneoctanoic acid methyl ester
• CAS No.: 56554-81-5
• Molecular Formula: C₁₈H₂₆O₅
• Molecular Weight: 322.401
• Mol file: 56554-81-5.mol

Synonyms:3-Methoxy-2-methoxycarbonylbenzeneoctanoic acid methyl ester

Chemical Property of 3-Methoxy-2-methoxycarbonylbenzeneoctanoic acid methyl ester

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Methoxy-2-methoxycarbonylbenzeneoctanoic acid methyl ester

There total 3 articles about 3-Methoxy-2-methoxycarbonylbenzeneoctanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

8-(3-methoxy-2-carbomethoxyphenyl)octanoic acid (109570-16-3) + methyl iodide (74-88-4) → methyl 8-(3-methoxy-2-carbomethoxyphenyl)octanoate (56554-81-5)

Guidance literature:

With potassium carbonate; In acetone; at 100 ℃; for 18h;

DOI:10.1021/acsmedchemlett.9b00071

Reference yield:

2-(8-hydroxy-octyl)-6-methoxy-benzoic acid methyl ester (83823-96-5) → methyl 8-(3-methoxy-2-carbomethoxyphenyl)octanoate (56554-81-5)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridinium chlorochromate / dichloromethane / 1 h / Cooling with ice

2: Jones reagent / acetone

3: potassium carbonate / acetone / 18 h / 100 °C

With Jones reagent; potassium carbonate; pyridinium chlorochromate; In dichloromethane; acetone;

DOI:10.1021/acsmedchemlett.9b00071

Reference yield:

2-Methoxy-6-(8-oxo-octyl)-benzoic acid methyl ester → methyl 8-(3-methoxy-2-carbomethoxyphenyl)octanoate (56554-81-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Jones reagent / acetone

2: potassium carbonate / acetone / 18 h / 100 °C

With Jones reagent; potassium carbonate; In acetone;

DOI:10.1021/acsmedchemlett.9b00071

upstream raw materials:

8-(3-methoxy-2-carbomethoxyphenyl)octanoic acid

methyl iodide

2-(8-hydroxy-octyl)-6-methoxy-benzoic acid methyl ester