1-BOC-(R)-3-(2-METHOXYETHOXY)PYRROLIDINE

Base Information

• Chemical Name: 1-BOC-(R)-3-(2-METHOXYETHOXY)PYRROLIDINE
• CAS No.: 916792-33-1
• Molecular Formula: C₁₂H₂₃NO₄
• Molecular Weight: 245.319
• Hs Code.: 2933990090
• Mol file: 916792-33-1.mol

Synonyms:1-BOC-(R)-3-(2-METHOXYETHOXY)PYRROLIDINE

Chemical Property of 1-BOC-(R)-3-(2-METHOXYETHOXY)PYRROLIDINE

Chemical Property:

• PSA: 48.00000
• LogP: 1.59670

Purity/Quality:

99% ^*data from raw suppliers

3-(2-METHOXY-ETHOXY)-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BOC-(R)-3-(2-METHOXYETHOXY)PYRROLIDINE

There total 2 articles about 1-BOC-(R)-3-(2-METHOXYETHOXY)PYRROLIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

(R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate (109431-87-0,83220-73-9) + 2-Bromoethyl methyl ether (6482-24-2) → tert-butyl (R)-3-(2-methoxyethoxy)pyrrolidine-1-carboxylate (1212413-55-2,916792-33-1)

Guidance literature:

(R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

2-Bromoethyl methyl ether; In tetrahydrofuran; mineral oil; at 20 ℃;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl (R)-3-(2-methoxyethoxy)pyrrolidine-1-carboxylate (1212413-55-2,916792-33-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0.12 h / 0 - 20 °C

2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2.2: 20 °C

With sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; mineral oil;

Reference yield:

tert-butyl (R)-3-(2-methoxyethoxy)pyrrolidine-1-carboxylate (1212413-55-2,916792-33-1) → (R)-3-(2-methoxyethoxy)pyrrolidine (942618-26-0,880362-02-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

DOI:10.1021/jm201702g

upstream raw materials:

(R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate

2-Bromoethyl methyl ether

di-tert-butyl dicarbonate

Downstream raw materials:

(R)-3-(2-methoxyethoxy)pyrrolidine