Tolperisone 4-Carboxylic Acid Hydrochloride Hydrate

Base Information

• Chemical Name: Tolperisone 4-Carboxylic Acid Hydrochloride Hydrate
• CAS No.: 446063-44-1
• Molecular Formula: C₁₆H₂₁NO₃*ClH
• Molecular Weight: 311.809
• Mol file: 446063-44-1.mol

Synonyms:Tolperisone 4-Carboxylic Acid Hydrochloride Hydrate;4-[2-Methyl-1-oxo-3-(1-piperidinyl)propyl]benzoic Acid Hydrochloride Hydrate;Carboxy Tolperisone Hydrochloride

Chemical Property of Tolperisone 4-Carboxylic Acid Hydrochloride Hydrate

Chemical Property:

• PSA: 57.61000
• LogP: 3.42940
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly), Water (Sparingly)

Purity/Quality:

98%min ^*data from raw suppliers

Tolperisone4-CarboxylicAcidHydrochlorideHydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Tolperisone 4-Carboxylic Acid Hydrochloride Hydrate

There total 3 articles about Tolperisone 4-Carboxylic Acid Hydrochloride Hydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

(S)-1-(4-hydroxymethylphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one (352233-17-1) → (S)-1-(4-carboxyphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one hydrochloride (446063-44-1)

Guidance literature:

(S)-1-(4-hydroxymethylphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one; With chromium(VI) oxide; sulfuric acid; In water; acetone; at 40 - 45 ℃; for 1h;

With hydrogenchloride; In diethyl ether; isopropyl alcohol;

DOI:10.1016/S0957-4166(02)00025-3

Reference yield: 52.0%

(R)-1-(4-hydroxymethylphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one (352233-15-9) → (R)-1-(4-carboxyphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one hydrochloride (446063-44-1)

Guidance literature:

(R)-1-(4-hydroxymethylphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one; With chromium(VI) oxide; sulfuric acid; In water; acetone; at 40 - 45 ℃; for 1h;

With hydrogenchloride; In diethyl ether; isopropyl alcohol;

DOI:10.1016/S0957-4166(02)00025-3

Reference yield:

1-[4-(hydroxymethyl)phenyl]propan-1-one (352233-12-6) → (+/-)-1-(4-carboxyphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one hydrochloride (446063-44-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / TEBA; KMnO₄ / H₂O / 10 - 15 °C

2: 43 percent / HCl / ethanol / 2.5 h / 100 - 110 °C

With hydrogenchloride; potassium permanganate; N-benzyl-N,N,N-triethylammonium chloride; In ethanol; water;

DOI:10.1016/S0957-4166(02)00025-3

upstream raw materials:

1-[4-(hydroxymethyl)phenyl]propan-1-one

(R)-1-(4-hydroxymethylphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one

(S)-1-(4-hydroxymethylphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one