(R)-1-(4-hydroxymethylphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one

Base Information

• Chemical Name: (R)-1-(4-hydroxymethylphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one
• CAS No.: 352233-15-9
• Molecular Formula: C₁₆H₂₃NO₂
• Molecular Weight: 261.364
• Mol file: 352233-15-9.mol

Synonyms:(R)-1-(4-hydroxymethylphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one

Chemical Property of (R)-1-(4-hydroxymethylphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-(4-hydroxymethylphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one

There total 4 articles about (R)-1-(4-hydroxymethylphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + piperidine hydrochloride (6091-44-7) + 1-[4-(hydroxymethyl)phenyl]propan-1-one (352233-12-6) → (R)-1-(4-hydroxymethylphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one (352233-15-9) + (S)-1-(4-hydroxymethylphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one (352233-17-1)

Guidance literature:

formaldehyd; piperidine hydrochloride; 1-[4-(hydroxymethyl)phenyl]propan-1-one; With hydrogenchloride; ethanol; at 100 - 110 ℃; for 2h;

With Di-p-toluoyl-L-tartaric acid; acetic acid; In ethyl acetate; acetone; for 2h;

DOI:10.1016/S0957-4166(01)00088-X

Reference yield:

4'-methylpropiophenone (5337-93-9) → (R)-1-(4-hydroxymethylphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one (352233-15-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 52.9 percent / N-bromosuccinimide; benzoyl peroxide / CCl₄ / Heating

2.1: 84.4 percent / acetic acid / 2 h / Heating

3.1: 91 percent / NaOH; H₂O / methanol / 0.25 h / Heating

4.1: HCl; EtOH / 2 h / 100 - 110 °C

4.2: (2R,3R)-O,O'-di-p-toluoyltartaric acid; AcOH / acetone; ethyl acetate / 2 h

With hydrogenchloride; sodium hydroxide; N-Bromosuccinimide; ethanol; water; dibenzoyl peroxide; In methanol; tetrachloromethane; acetic acid; 4.1: Mannich reaction;

DOI:10.1016/S0957-4166(01)00088-X

Reference yield:

1-(4-(bromomethyl)phenyl)propan-1-one (95889-09-1) → (R)-1-(4-hydroxymethylphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one (352233-15-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 84.4 percent / acetic acid / 2 h / Heating

2.1: 91 percent / NaOH; H₂O / methanol / 0.25 h / Heating

3.1: HCl; EtOH / 2 h / 100 - 110 °C

3.2: (2R,3R)-O,O'-di-p-toluoyltartaric acid; AcOH / acetone; ethyl acetate / 2 h

With hydrogenchloride; sodium hydroxide; ethanol; water; In methanol; acetic acid; 3.1: Mannich reaction;

DOI:10.1016/S0957-4166(01)00088-X

upstream raw materials:

formaldehyd

piperidine hydrochloride

1-[4-(hydroxymethyl)phenyl]propan-1-one

4'-methylpropiophenone

Downstream raw materials:

(R)-1-(4-carboxyphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one hydrochloride