Methyl 4-aMino-3-(MethylaMino)benzoate

Base Information

• Chemical Name: Methyl 4-aMino-3-(MethylaMino)benzoate
• CAS No.: 616224-38-5
• Molecular Formula: C9H12N2O2
• Molecular Weight: 180.206
• Hs Code.: 2922499990
• Mol file: 616224-38-5.mol

Synonyms:Methyl 4-aMino-3-(MethylaMino)benzoate

Chemical Property of Methyl 4-aMino-3-(MethylaMino)benzoate

Chemical Property:

• Boiling Point: 369.9±32.0 °C(Predicted)
• PKA: 4.42±0.10(Predicted)
• PSA: 64.35000
• Density: 1.208±0.06 g/cm3(Predicted)
• LogP: 1.75130
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%Min ^*data from raw suppliers

Methyl4-amino-3-(methylamino)benzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 4-aMino-3-(MethylaMino)benzoate

There total 4 articles about Methyl 4-aMino-3-(MethylaMino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 3-(methylamino)-4-nitrobenzoate (251643-13-7) → methyl 4-amino-3-(methylamino)benzoate (616224-38-5)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; for 16h;

Reference yield: 67.2%

4-tert-butoxycarbonylamino-3-methylaminobenzoic acid methyl ester (616224-36-3) → methyl 4-amino-3-(methylamino)benzoate (616224-38-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 0 - 20 ℃; for 1h;

Reference yield: 45.0%

carbon dioxide (124-38-9,18923-20-1) + Methyl 3,4-diaminobenzoate (36692-49-6) → methyl 4-amino-3-(methylamino)benzoate (616224-38-5)

Guidance literature:

With methanesulfonic acid; hydrogen; tris(acetylacetonato)ruthenium(III); [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine]; In tetrahydrofuran; at 140 ℃; Autoclave; Inert atmosphere;

DOI:10.1002/anie.201306850

upstream raw materials:

4-tert-butoxycarbonylamino-3-methylaminobenzoic acid methyl ester

methyl 3-(methylamino)-4-nitrobenzoate

carbon dioxide

Methyl 3,4-diaminobenzoate

Downstream raw materials:

methyl 1-methyl-1H-benzo[d]imidazole-6-carboxylate

3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxylic acid